FUSION PROTEIN CONSTRUCT TAKING INTERLEUKIN 15 AS ACTIVE INGREDIENT AND USE THEREOF

Title:

FUSION PROTEIN CONSTRUCT TAKING INTERLEUKIN 15 AS ACTIVE INGREDIENT AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/083379

Kind Code:

A1

Abstract:

The present invention relates to a fusion protein construct taking interleukin 15 as an active ingredient and the use thereof. Specifically, the fusion protein construct comprises: (1) a first structural unit: an α subunit sushi domain of an interleukin 15 (IL-15) receptor; (2) a second structural unit: IL-15; and (3) a third structural unit: an antibody Fc or a mutated Fc fragment; and a key linking fragment 1, wherein the amino acid sequence of the linking fragment 1 is an integer multiple repetition of GGGGS.

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Inventors:

FU YANGXIN (CN)
PENG HUA (CN)
SHEN JIAO (CN)

Application Number:

PCT/CN2022/132019

Publication Date:

May 19, 2023

Filing Date:

November 15, 2022

Export Citation:

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Assignee:

INST BIOPHYSICS CAS (CN)

International Classes:

C07K19/00; A61K38/20; A61K39/395; A61P35/00; C07K14/54; C07K14/715; C07K16/28; C12N15/62; C12N15/85

Domestic Patent References:

WO2021113577A1

2021-06-10

Foreign References:

CN113480662A	2021-10-08
CN110437339A	2019-11-12
CN104093841A	2014-10-08
CN112513070A	2021-03-16
CN113321736A	2021-08-31

Attorney, Agent or Firm:

BEIJING CHENGHUI LAW FIRM (CN)

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