Title:
FUSION PROTEIN CONTAINING HUMAN INTERLEUKIN-10 AND FC FRAGMENT AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/068752
Kind Code:
A1
Abstract:
Provided are a fusion protein and the medical use thereof. The fusion protein is prepared by fusing a human interleukin-10 (IL-10) with an Fc fragment of an immunoglobulin IgG via a linker peptide. The Fc fragment is the Fc fragment of human IgG1, human IgG2 and human IgG4, and the human interleukin-10 comprises the amino acid sequence as shown in SEQ ID NO: 1. The fusion protein can be used for the treatment of immunological diseases and cancers, and prolongs the in vivo half-life of human IL-10 and increases the in vivo stability of human IL-10.
Inventors:
BAI YI (CN)
ZHANG WEN (CN)
ZHOU JIANHUA (CN)
ZHANG WEN (CN)
ZHOU JIANHUA (CN)
Application Number:
PCT/CN2020/117341
Publication Date:
April 15, 2021
Filing Date:
September 24, 2020
Export Citation:
Assignee:
BEIJING DONGFANG BIOTECH CO LTD (CN)
International Classes:
C07K19/00; A61K38/20; C07K14/54; C07K16/00
Foreign References:
| CN108948207A | 2018-12-07 | |||
| US20170368144A1 | 2017-12-28 | |||
| CN101948543A | 2011-01-19 | |||
| CN104540848A | 2015-04-22 | |||
| CN103525868A | 2014-01-22 |
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
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