Title:
FUSION PROTEIN CONTAINING IMPROVED GLP-1 RECEPTOR AGONIST AND USES
Document Type and Number:
WIPO Patent Application WO/2023/246928
Kind Code:
A1
Abstract:
The present invention relates to an improved GLP-1 receptor agonist, a fusion protein containing the improved GLP-1 receptor agonist, a polynucleotide encoding the fusion protein, a vector containing the polynucleotide, a cell, and the uses thereof. Particularly, the present invention provides a modification-improved GLP-1-IgG2/Fc fusion protein, a polynucleotide encoding the fusion protein, a vector containing the polynucleotide, a cell, and a composition thereof. The present invention also relates to the uses of the fusion protein, the polynucleotide, the vector, the cell and the composition in drugs, and/or the uses thereof in the preparation of drugs for treating or preventing metabolic diseases related to carbohydrate metabolism and/or lipid metabolism disorders, nervous system diseases, and other related diseases.
Inventors:
WANG QINGHUA (CN)
Application Number:
PCT/CN2023/101978
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
GUANGZHOU INNOGEN PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI INNOGEN PHARMACEUTICAL TECH CO LTD (CN)
SHANGHAI INNOGEN BIOMEDICAL ENG CO LTD (CN)
SHANGHAI INNOGEN PHARMACEUTICAL TECH CO LTD (CN)
SHANGHAI INNOGEN BIOMEDICAL ENG CO LTD (CN)
International Classes:
C07K19/00; A61K38/16; A61K45/06; C07K14/00; C07K14/605
Foreign References:
| US20160310575A1 | 2016-10-27 | |||
| CN114395597A | 2022-04-26 | |||
| CN1322137A | 2001-11-14 | |||
| CN106659770A | 2017-05-10 |
Other References:
YANG YI, CHEN FANG, WAN DEYOU, LIU YUNHUI, YANG LI, FENG HONGRU, CUI XINLING, GAO XIN, SONG HAIFENG: "Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Agonist, GLP-1-IgG2σ-Fc", PLOS ONE, vol. 11, no. 5, 27 May 2016 (2016-05-27), pages e0156449, XP055888358, DOI: 10.1371/journal.pone.0156449
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
Download PDF: