Title:
FUSION PROTEIN DISPLAYING SARS-COV-2 S PROTEIN, RECOMBINANT VIRION, AND USE OF FUSION PROTEIN AND RECOMBINANT VIRION
Document Type and Number:
WIPO Patent Application WO/2023/109979
Kind Code:
A3
Abstract:
Provided are a fusion protein displaying a SARS-COV-2 S protein, a recombinant virion, and a use of the fusion protein and the recombinant virion, belonging to the technical field of biological products. Provided are a fusion gene expressing a SARS-COV-2 S protein, and a fusion protein, wherein the fusion gene or fusion protein contains the sequence of an extracellular domain of a SARS-COV-2 S protein and the sequences of a transmembrane domain and an intracellular domain of an Avian paramyxovirus (APMV) F protein. Meanwhile, a recombinant NDV virus containing said sequences has a strong ability to neutralize an antibody. It is apparent that the fusion gene or protein formed by means of fusing a sequence encoding an extracellular domain of an S protein with sequences encoding a transmembrane domain and an intracellular domain of an APMV (excluding NDV) F protein has great potential to be an excellent candidate antigen for a SARS-COV-2 vaccine.
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Inventors:
CHEN RUITING (CN)
SUN HUIMIN (CN)
MAO SHUIHUA (CN)
ZHOU MENGYUN (CN)
SONG JIASHENG (CN)
SUN HUIMIN (CN)
MAO SHUIHUA (CN)
ZHOU MENGYUN (CN)
SONG JIASHENG (CN)
Application Number:
PCT/CN2023/076443
Publication Date:
August 03, 2023
Filing Date:
February 16, 2023
Export Citation:
Assignee:
ZHEJIANG DIFFERENCE BIOLOGICAL TECH CO LTD (CN)
International Classes:
C07K19/00; A61K39/155; A61K39/215; A61P11/00; A61P31/14; C12N7/01; C12N15/62; C12N15/86; C12R1/93
Domestic Patent References:
| WO2021226348A2 | 2021-11-11 | |||
| WO2021206581A1 | 2021-10-14 |
Foreign References:
| CN114213547A | 2022-03-22 | |||
| US11179459B1 | 2021-11-23 |
Other References:
SUN WEINA, SUN WEINA, LEIST SARAH, MCCROSKERY STEPHEN, LIU YONGHONG, SLAMANIG STEFAN, OLIVA JUSTINE, AMANAT FATIMA, SCHÄFER ALEXAN: "Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate", EBIOMEDICINE, ELSEVIER BV, NL, vol. 62, 1 December 2020 (2020-12-01), NL , pages 103132, XP055872539, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2020.103132
YANG, YUYING; ZUO, DAIYING: "Progress on the Research of Novel Coronavirus Vaccine", JOURNAL OF SHENYANG PHARMACEUTICAL, vol. 38, no. 7, 31 July 2021 (2021-07-31), LIAONING, CN , pages 762 - 769, XP009548115, ISSN: 1006-2858, DOI: 10.14066/j.cnki.cn21-1349/r.2021.0143
YANG, YUYING; ZUO, DAIYING: "Progress on the Research of Novel Coronavirus Vaccine", JOURNAL OF SHENYANG PHARMACEUTICAL, vol. 38, no. 7, 31 July 2021 (2021-07-31), LIAONING, CN , pages 762 - 769, XP009548115, ISSN: 1006-2858, DOI: 10.14066/j.cnki.cn21-1349/r.2021.0143
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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