Title:
FUSION PROTEIN INCLUDING GLP-1 RECEPTOR AGONIST AND ANTI-OSCAR ANTIBODY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/119076
Kind Code:
A1
Abstract:
The present invention relates to: a fusion protein including a glucagon like peptide-1 (GLP-1) receptor agonist and an anti-osteoclast-associated receptor (OSCAR) antibody; a pharmaceutical composition for preventing or treating arthritis, comprising the fusion protein; a food composition; a health functional composition; and a method for preventing or treating arthritis, comprising a step of administering the pharmaceutical composition. The fusion protein including a GLP-1 receptor agonist and an anti-OSCAR antibody of the present invention has excellent effects of cartilage protection and pain relief, and thus can be widely used in the effective treatment of arthritis.
Inventors:
HUR BYUNGUNG (KR)
CHOI HYOJUNG (KR)
SON YEWON (KR)
KIM WOOSIK (KR)
KANG HYOJIN (KR)
KWON HYUNJIN (KR)
AHN SUNGMIN (KR)
CHANG KIHO (KR)
CHOI HYOJUNG (KR)
SON YEWON (KR)
KIM WOOSIK (KR)
KANG HYOJIN (KR)
KWON HYUNJIN (KR)
AHN SUNGMIN (KR)
CHANG KIHO (KR)
Application Number:
PCT/KR2021/009934
Publication Date:
June 09, 2022
Filing Date:
July 29, 2021
Export Citation:
Assignee:
IMMUNOFORGE CO LTD (KR)
International Classes:
C07K14/605; A23L33/18; A61K38/00; A61P19/02; C07K16/28
Domestic Patent References:
| WO2013011063A1 | 2013-01-24 |
Foreign References:
| US20140056918A1 | 2014-02-27 |
Other References:
QUE QIHONG, GUO XINGHUA, ZHAN LONGXIN, CHEN SHAODONG, ZHANG ZENGLI, NI XIAOMING, YE BIN, WAN SHUANGLIN: "The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis", JOURNAL OF INFLAMMATION, vol. 16, no. 1, 1 December 2019 (2019-12-01), XP055938361, DOI: 10.1186/s12950-019-0218-y
JIAN CHEN, JUN-JUN XIE, KE-SI SHI, YUN-TAO GU, CONG-CONG WU, JUN XUAN, YUE REN, LONG CHEN, YAO-SEN WU, XIAO-LEI ZHANG, JIAN XIAO, : "Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat", CELL DEATH & DISEASE, vol. 9, no. 2, 1 February 2018 (2018-02-01), XP055609622, DOI: 10.1038/s41419-017-0217-y
N SOLTANI, ET AL: "In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 14, 5 April 2007 (2007-04-05) - 05-04-2007, GB , pages 981 - 988, XP002499674, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302944
PARK DOO RI, KIM JIHEE, KIM GYEONG MIN, LEE HAESEUNG, KIM MINHEE, HWANG DONGHYUN, LEE HANA, KIM HAN-SUNG, KIM WANKYU, PARK MIN CHA: "Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055938368, DOI: 10.1038/s41467-020-18208-y
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, vol. 24, 2010, pages 121 - 132
JIAN CHEN, JUN-JUN XIE, KE-SI SHI, YUN-TAO GU, CONG-CONG WU, JUN XUAN, YUE REN, LONG CHEN, YAO-SEN WU, XIAO-LEI ZHANG, JIAN XIAO, : "Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat", CELL DEATH & DISEASE, vol. 9, no. 2, 1 February 2018 (2018-02-01), XP055609622, DOI: 10.1038/s41419-017-0217-y
N SOLTANI, ET AL: "In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 14, 5 April 2007 (2007-04-05) - 05-04-2007, GB , pages 981 - 988, XP002499674, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302944
PARK DOO RI, KIM JIHEE, KIM GYEONG MIN, LEE HAESEUNG, KIM MINHEE, HWANG DONGHYUN, LEE HANA, KIM HAN-SUNG, KIM WANKYU, PARK MIN CHA: "Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055938368, DOI: 10.1038/s41467-020-18208-y
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, vol. 24, 2010, pages 121 - 132
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
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