Title:
FUSION PROTEIN, NUCLEIC ACID, VECTOR, CELL, METHOD FOR MEASURING LAB, AND KIT FOR USE IN MEASUREMENT OF LAB
Document Type and Number:
WIPO Patent Application WO/2013/190679
Kind Code:
A1
Abstract:
Provided is a fusion protein produced by linking full-length apolipoprotein B (ApoB) or a partial fragment thereof to a protein capable of binding specifically to lectin-like oxidized LDL receptor (LOX-1). An example of the protein capable of binding specifically to LOX-1 is an antibody against LOX-1. The antibody may have the form of a functional fragment of the antibody. Also provided are: a method for measuring LAB using the fusion protein as an LAB reference standard; and a kit for use in the measurement of LAB, which contains the fusion protein.
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Inventors:
IWAMOTO SHIN (JP)
SAWAMURA TATSUYA (JP)
SAWAMURA TATSUYA (JP)
Application Number:
PCT/JP2012/065873
Publication Date:
December 27, 2013
Filing Date:
June 21, 2012
Export Citation:
Assignee:
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
BIOMARKER SCIENCE CO LTD (JP)
IWAMOTO SHIN (JP)
SAWAMURA TATSUYA (JP)
BIOMARKER SCIENCE CO LTD (JP)
IWAMOTO SHIN (JP)
SAWAMURA TATSUYA (JP)
International Classes:
C12N15/09; C07K14/775; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53
Foreign References:
| JP2012100585A | 2012-05-31 | |||
| JP2011106847A | 2011-06-02 | |||
| JPH0998787A | 1997-04-15 |
Other References:
IWAMOTO S ET AL.: "An Alternative Protein Standard to Measure Activity of LOX-1 Ligand Containing apoB (LAB) - Utilization of Anti- LOX-1 Single- Chain Antibody Fused to apoB Fragment", JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, vol. 18, no. 9, 27 September 2011 (2011-09-27), pages 818 - 828
SHIN IWAMOTO ET AL.: "Sanka LDL Sokutei no Tameno Jinko Hyojun Tanpaku Sakusei", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 82, no. 11, 25 November 2010 (2010-11-25), pages 3P-1146
INOUE N ET AL.: "LOX index, a novel predictive biochemical marker for coronary heart disease and stroke", CLIN. CHEM., vol. 56, no. 4, April 2010 (2010-04-01), pages 550 - 558
SHIN IWAMOTO ET AL.: "Sanka LDL Sokutei no Tameno Jinko Hyojun Tanpaku Sakusei", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 82, no. 11, 25 November 2010 (2010-11-25), pages 3P-1146
INOUE N ET AL.: "LOX index, a novel predictive biochemical marker for coronary heart disease and stroke", CLIN. CHEM., vol. 56, no. 4, April 2010 (2010-04-01), pages 550 - 558
Attorney, Agent or Firm:
FUJITA Takashi et al. (JP)
Takashi Fujita (JP)
Takashi Fujita (JP)
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