Title:
FUSION PROTEIN OF RELAXIN OR ANALOGUE AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/216981
Kind Code:
A1
Abstract:
The present disclosure relates to a fusion protein of relaxin or an analogue and the medical use thereof. Specifically, the present disclosure relates to a fusion protein comprising relaxin or an analogue thereof and a serum albumin binding domain, and the medical use thereof for treating diseases (for example, heart failure). Moreover, the present disclosure relates to a serum albumin binding molecule, which comprises an immunoglobulin single variable domain (for example, VHH) capable of binding to serum albumin, has good plasma stability, and can be used for prolonging the plasma half-life of a drug.
Inventors:
DU YANPING (CN)
WANG LEI (CN)
LIU XIAO (CN)
GAO HONG (CN)
SHEN CHENXI (CN)
ZHANG LINSHUANG (CN)
JIANG PENG (CN)
WANG LEI (CN)
LIU XIAO (CN)
GAO HONG (CN)
SHEN CHENXI (CN)
ZHANG LINSHUANG (CN)
JIANG PENG (CN)
Application Number:
PCT/CN2023/092214
Publication Date:
November 16, 2023
Filing Date:
May 05, 2023
Export Citation:
Assignee:
BEIJING TUO JIE BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/18; A61K39/395; A61P9/00; C07K16/46; C07K19/00; C12N15/13; C12N15/62
Foreign References:
| CN103649116A | 2014-03-19 | |||
| CN112851805A | 2021-05-28 | |||
| CN112409480A | 2021-02-26 | |||
| CA2766160A1 | 2002-08-08 | |||
| US20080260757A1 | 2008-10-23 | |||
| US20190352366A1 | 2019-11-21 | |||
| JP2014529293A | 2014-11-06 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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