Title:
FUSION PROTEIN FOR SUPPRESSING INFLUENZA VIRUS, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2022/071492
Kind Code:
A1
Abstract:
Disclosed is a fusion protein of an influenza-derived HA protein and an M1 protein, the fusion protein being a partially-deleted HA-M1 fusion protein in which an amino acid residue in a specific region has been deleted. This partially-deleted HA-M1 fusion protein has excellent characteristics.
Inventors:
SEKIKAWA KENJI (JP)
TAKAIWA FUMIO (JP)
KOBAYASHI OSAMU (JP)
KOMIYAMA YUTAKA (JP)
OHARA KAZUAKI (JP)
YAMAMURA EITORA (JP)
TAKAIWA FUMIO (JP)
KOBAYASHI OSAMU (JP)
KOMIYAMA YUTAKA (JP)
OHARA KAZUAKI (JP)
YAMAMURA EITORA (JP)
Application Number:
PCT/JP2021/036149
Publication Date:
April 07, 2022
Filing Date:
September 30, 2021
Export Citation:
Assignee:
KIRIN HOLDINGS KK (JP)
GREEN BIOMED INC (JP)
GREEN BIOMED INC (JP)
International Classes:
A01H1/00; C12N15/44; A61K39/145; A61P31/16; C07K14/11; C07K19/00; C12N1/19; C12N5/10; C12N15/62; C12N15/63; C12P21/02
Domestic Patent References:
| WO2019124557A1 | 2019-06-27 | |||
| WO2019145310A1 | 2019-08-01 |
Foreign References:
| JP2012521786A | 2012-09-20 |
Other References:
YASSINE HADI M., MCTAMNEY PATRICK M., BOYINGTON JEFFERY C., RUCKWARDT TRACY J., CRANK MICHELLE C., SMATTI MARIA K., LEDGERWOOD JUL: "Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), XP055920135, DOI: 10.1038/s41598-018-26538-7
KAROLINA URANOWSKA, TYBOROWSKA JOLANTA, JUREK ANNA, SZEWCZYK BOGUSÅAW, GROMADZKA BEATA: "Hemagglutinin stalk domain from H5N1 strain as a potentially universal antigen", ACTA BIOCHIMICA POLONICA, POLAND, 1 January 2014 (2014-01-01), Poland , pages 541, XP055213732, Retrieved from the Internet [retrieved on 20150916]
KAROLINA URANOWSKA, TYBOROWSKA JOLANTA, JUREK ANNA, SZEWCZYK BOGUSÅAW, GROMADZKA BEATA: "Hemagglutinin stalk domain from H5N1 strain as a potentially universal antigen", ACTA BIOCHIMICA POLONICA, POLAND, 1 January 2014 (2014-01-01), Poland , pages 541, XP055213732, Retrieved from the Internet
Attorney, Agent or Firm:
NAKAMURA Yukitaka et al. (JP)
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