Title:
FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO/2019/163871
Kind Code:
A1
Abstract:
The present invention provides a prospective means for use in a novel drug delivery system (DDS), an electronic device production, etc. More particularly, the present invention provides: a fusion protein containing (a) a ferritin monomer, and (b) a functional peptide inserted in a flexible linker region between α-helices of B- and C-regions in the ferritin monomer; and a polymer which has a lumen and is composed of a fusion protein containing (a) a ferritin monomer, and (b) a functional peptide inserted in a flexible linker region between α-helices of B- and C-regions in the ferritin monomer.
Inventors:
INOUE IPPEI (JP)
Application Number:
PCT/JP2019/006473
Publication Date:
August 29, 2019
Filing Date:
February 21, 2019
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C12N15/62; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63
Domestic Patent References:
| WO2012086647A1 | 2012-06-28 | |||
| WO2006126595A1 | 2006-11-30 | |||
| WO2012086647A1 | 2012-06-28 | |||
| WO2005010031A1 | 2005-02-03 |
Foreign References:
| US20160060307A1 | 2016-03-03 | |||
| US20160060307A1 | 2016-03-03 | |||
| JP2004121154A | 2004-04-22 |
Other References:
ZHANG, YU ET AL.: "Self-Assembly in the Ferritin Nano-Cage Protein Superfamily", INT. J. MOL. SCI., vol. 12, no. 12, 22 August 2011 (2011-08-22), pages 5406 - 5421, XP055427570, DOI: 10.3390/ijms12085406
KIM, SOO-JI ET AL.: "Designing Peptide Bunches on Nanocage for Bispecific or Superaffinity Targeting", BIOMACROMOLECULES, vol. 17, no. 3, 22 February 2016 (2016-02-22), pages 1150 - 1159, XP055633374
JI, TIANJIAO ET AL.: "Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging", SMALL, vol. 9, no. 14, 22 July 2013 (2013-07-22), pages 2427 - 2431, XP055633376
CARMONA, FERNANDO ET AL.: "Study of ferritin self- assembly and heteropolymer formation by the use of Fluorescence Resonance Energy Transfer (FRET) technology", BBA, vol. 1861, 18 December 2016 (2016-12-18), pages 522 - 532, XP029897101, DOI: 10.1016/j.bbagen.2016.12.011
K. SANO ET AL., NANO LETT., vol. 7, 2007, pages 3200
JAE OG JEON ET AL., ACS NANO, vol. 7, no. 9, 2013, pages 7462 - 7471
SOOJI KIM ET AL., BIOMACROMOLECULES, vol. 17, no. 2, 2016, pages 1150 - 1159
YOUNG JI KANG ET AL., BIOMACROMOLECULES, vol. 13, no. 12, 2012, pages 4057 - 4064
T. HAIKARAINENA. C. PAPAGEORGION, CELL. MOL. LIFE SCI., vol. 67, 2010, pages 341
PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
J MOL BIOL, vol. 48, 1970, pages 443 - 453
F. DANHIER ET AL., MOL. PHARMACEUTICS, vol. 9, no. 11, 2012, pages 2961
C-H. WU ET AL., SCI. TRANSL. MED., vol. 7, no. 290, 2015, pages 290ra91
L. VANNUCCI ET AL., INT. J. NANOMEDICINE, vol. 7, 2012, pages 1489
J. CUTRERA ET AL., MOL. THER., vol. 19, no. 8, 2011, pages 1468
R. LIU ET AL., ADV. DRUG DELIV. REV., vol. 110-111, 2017, pages 13
R. TAN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 5282
R. TAN ET AL., CELL, vol. 73, 1993, pages 1031
R. TALANIAN ET AL., BIOCHEMISTRY, vol. 31, 1992, pages 6871
K. OLDENBURG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, no. l2, 1992, pages 5393 - 5397
K. YAMAMOTO ET AL., J. BIOCHEM., vol. 111, 1992, pages 436
A. BAIMIEV ET AL., MOL. BIOL. (MOSCOW, vol. 39, no. 1, 2005, pages 90
O. KRUSE ET AL., B Z. NATURFORSCH., vol. 50c, 1995, pages 380
0. SILVA ET AL., SCI. REP., vol. 6, 2016, pages 27128
A. FILOTEO ET AL., J. BIOL. CHEM., vol. 267, no. 17, 1992, pages 11800
O. KRUSE ET AL., Z. NATURFORSCH., vol. 50c, 1995, pages 380
K. SANO ET AL., LANGMUIR, vol. 21, 2004, pages 3090
S. BROWN, NAT. BIOTECHNOL., vol. 15, 1997, pages 269
K. KJAERGAARD ET AL., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 10
M. UMETSU ET AL., ADV. MATER., vol. 17, 2005, pages 2571 - 2575
M. B. DICKERSON ET AL., CHEM. COMMUN., vol. 15, 2004, pages 1776
C. E. FLYNN ET AL., J. MATER. CHEM., vol. 13, 2003, pages 2414
M. J. PENDER ET AL., NANO LETT., vol. 6, no. 1, 2006, pages 40 - 44
I. INOUE ET AL., J. BIOSCI. BIOENG., vol. 122, no. 5, 2006, pages 528
J. KIM ET AL., ACTA BIOMATER., vol. 6, no. 7, 2010, pages 2681
K. NAM, SCIENCE, vol. 312, no. 5775, 2006, pages 885
D. MCILWAINL ET AL., COLD SPRING HARB PERSPECT BIOL., vol. 5, 2013, pages a008656
V. STOKA ET AL., IUBMB LIFE, vol. 57, no. 4-5, 2005, pages 347
G. LEE ET AL., EUR J PHARM BIOPHARM., vol. 67, no. 3, 2007, pages 646
R. JENNY ET AL., PROTEIN EXPR. PURIF., vol. 31, 2003, pages 1
H. XU ET AL., J. VIROL., vol. 84, no. 2, 2010, pages 1076
C. BYRD ET AL., DRUG DEV. RES., vol. 67, 2006, pages 501
E. LEE ET AL., ADV. FUNCT. MATER., vol. 25, 2015, pages 1279
R. TALANIAN ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 9677
X. MENG ET AL., NANOSCALE, vol. 3, no. 3, 2011, pages 977
Z. GUO ET AL., BIOMED. REP., vol. 4, no. 5, 2016, pages 528
B. ZHENG ET AL., NANOTECHNOLOGY, vol. 21, 2010, pages 445602
R. M. KRAMER ET AL., J. AM. CHEM. SOC., vol. 126, 2004, pages 13282
I. YAMASHITA ET AL., CHEM. LETT., vol. 33, 2005, pages 1158
INT. J. MOL. SCI., vol. 12, no. 8, 2011, pages 5406 - 5421
See also references of EP 3757218A4
KIM, SOO-JI ET AL.: "Designing Peptide Bunches on Nanocage for Bispecific or Superaffinity Targeting", BIOMACROMOLECULES, vol. 17, no. 3, 22 February 2016 (2016-02-22), pages 1150 - 1159, XP055633374
JI, TIANJIAO ET AL.: "Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging", SMALL, vol. 9, no. 14, 22 July 2013 (2013-07-22), pages 2427 - 2431, XP055633376
CARMONA, FERNANDO ET AL.: "Study of ferritin self- assembly and heteropolymer formation by the use of Fluorescence Resonance Energy Transfer (FRET) technology", BBA, vol. 1861, 18 December 2016 (2016-12-18), pages 522 - 532, XP029897101, DOI: 10.1016/j.bbagen.2016.12.011
K. SANO ET AL., NANO LETT., vol. 7, 2007, pages 3200
JAE OG JEON ET AL., ACS NANO, vol. 7, no. 9, 2013, pages 7462 - 7471
SOOJI KIM ET AL., BIOMACROMOLECULES, vol. 17, no. 2, 2016, pages 1150 - 1159
YOUNG JI KANG ET AL., BIOMACROMOLECULES, vol. 13, no. 12, 2012, pages 4057 - 4064
T. HAIKARAINENA. C. PAPAGEORGION, CELL. MOL. LIFE SCI., vol. 67, 2010, pages 341
PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
J MOL BIOL, vol. 48, 1970, pages 443 - 453
F. DANHIER ET AL., MOL. PHARMACEUTICS, vol. 9, no. 11, 2012, pages 2961
C-H. WU ET AL., SCI. TRANSL. MED., vol. 7, no. 290, 2015, pages 290ra91
L. VANNUCCI ET AL., INT. J. NANOMEDICINE, vol. 7, 2012, pages 1489
J. CUTRERA ET AL., MOL. THER., vol. 19, no. 8, 2011, pages 1468
R. LIU ET AL., ADV. DRUG DELIV. REV., vol. 110-111, 2017, pages 13
R. TAN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 5282
R. TAN ET AL., CELL, vol. 73, 1993, pages 1031
R. TALANIAN ET AL., BIOCHEMISTRY, vol. 31, 1992, pages 6871
K. OLDENBURG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, no. l2, 1992, pages 5393 - 5397
K. YAMAMOTO ET AL., J. BIOCHEM., vol. 111, 1992, pages 436
A. BAIMIEV ET AL., MOL. BIOL. (MOSCOW, vol. 39, no. 1, 2005, pages 90
O. KRUSE ET AL., B Z. NATURFORSCH., vol. 50c, 1995, pages 380
0. SILVA ET AL., SCI. REP., vol. 6, 2016, pages 27128
A. FILOTEO ET AL., J. BIOL. CHEM., vol. 267, no. 17, 1992, pages 11800
O. KRUSE ET AL., Z. NATURFORSCH., vol. 50c, 1995, pages 380
K. SANO ET AL., LANGMUIR, vol. 21, 2004, pages 3090
S. BROWN, NAT. BIOTECHNOL., vol. 15, 1997, pages 269
K. KJAERGAARD ET AL., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 10
M. UMETSU ET AL., ADV. MATER., vol. 17, 2005, pages 2571 - 2575
M. B. DICKERSON ET AL., CHEM. COMMUN., vol. 15, 2004, pages 1776
C. E. FLYNN ET AL., J. MATER. CHEM., vol. 13, 2003, pages 2414
M. J. PENDER ET AL., NANO LETT., vol. 6, no. 1, 2006, pages 40 - 44
I. INOUE ET AL., J. BIOSCI. BIOENG., vol. 122, no. 5, 2006, pages 528
J. KIM ET AL., ACTA BIOMATER., vol. 6, no. 7, 2010, pages 2681
K. NAM, SCIENCE, vol. 312, no. 5775, 2006, pages 885
D. MCILWAINL ET AL., COLD SPRING HARB PERSPECT BIOL., vol. 5, 2013, pages a008656
V. STOKA ET AL., IUBMB LIFE, vol. 57, no. 4-5, 2005, pages 347
G. LEE ET AL., EUR J PHARM BIOPHARM., vol. 67, no. 3, 2007, pages 646
R. JENNY ET AL., PROTEIN EXPR. PURIF., vol. 31, 2003, pages 1
H. XU ET AL., J. VIROL., vol. 84, no. 2, 2010, pages 1076
C. BYRD ET AL., DRUG DEV. RES., vol. 67, 2006, pages 501
E. LEE ET AL., ADV. FUNCT. MATER., vol. 25, 2015, pages 1279
R. TALANIAN ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 9677
X. MENG ET AL., NANOSCALE, vol. 3, no. 3, 2011, pages 977
Z. GUO ET AL., BIOMED. REP., vol. 4, no. 5, 2016, pages 528
B. ZHENG ET AL., NANOTECHNOLOGY, vol. 21, 2010, pages 445602
R. M. KRAMER ET AL., J. AM. CHEM. SOC., vol. 126, 2004, pages 13282
I. YAMASHITA ET AL., CHEM. LETT., vol. 33, 2005, pages 1158
INT. J. MOL. SCI., vol. 12, no. 8, 2011, pages 5406 - 5421
See also references of EP 3757218A4
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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