Title:
FXR AGONIST AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/128896
Kind Code:
A1
Abstract:
Disclosed are an FXR agonist and a preparation method and use thereof, in particular relating to the compound having the structure of formula (I), a stereisomer or a pharmaceutically acceptable salt thereof. The series of compounds can be used to treat FXR mediated diseases, comprising cardiovascular disease, atherosclerosis, arteriosclerosis, hypercholesterolemia, hyperlipidemia and chronic hepatitis, chronic liver disease, gastrointestinal diseases, kidney diseases, metabolic diseases, cancers (such as colorectal cancer) or neurological conditions such as strokes etc., have a wide medical application, and have a promising future for being developed into a new generation of FXR regulating agents.
Inventors:
HUANG MENGLIN (CN)
BAO RUDI (CN)
LI YUANNIAN (CN)
BAO RUDI (CN)
LI YUANNIAN (CN)
Application Number:
PCT/CN2016/111652
Publication Date:
August 03, 2017
Filing Date:
December 23, 2016
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
C07D275/02; A61K31/42; A61K31/425; A61K31/427; A61K31/4439; A61P9/00; C07D261/08; C07D413/12; C07D413/14; C07D417/12; C07D417/14
Domestic Patent References:
| WO2013037482A1 | 2013-03-21 |
Foreign References:
| CN103702719A | 2014-04-02 | |||
| CN102548974A | 2012-07-04 | |||
| CN101374834A | 2009-02-25 | |||
| EP3034499A1 | 2016-06-22 |
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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