Title:
GADOLINIUM CHELATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/199028
Kind Code:
A1
Abstract:
A gadolinium chelate, a preparation method therefor, and an application thereof. The gadolinium chelate is a complex formed by chelation of gadolinium ions and macromolecules. The macromolecules comprise any one of or a copolymer or mixture of two or more of carboxylic acid-containing high-molecular polymers, amino-containing high-molecular polymers, hydroxyl-containing high-molecular polymers, polyester high-molecular polymers, polyether high-molecular polymers, polyamide high-molecular polymers, proteins, polypeptides, and polysaccharides. The gadolinium ions and the macromolecules form the gadolinium chelate by means of chelation. The gadolinium chelate is a water-soluble macromolecular drug, can improve a longitudinal relaxation rate r1 and reduce a ratio of r2/r1, has good water-solubility and high stability, and meanwhile, can exhibit a good imaging effect in a short period of time and shorten an MRI time.
Inventors:
SHEN ZHEYU (CN)
LU YUDIE (CN)
LU YUDIE (CN)
Application Number:
PCT/CN2021/127915
Publication Date:
September 29, 2022
Filing Date:
November 01, 2021
Export Citation:
Assignee:
SOUTH MEDICAL UNIV (CN)
International Classes:
C08F8/42; A61K49/12; A61K49/14; C08B37/08
Foreign References:
| CN112940157A | 2021-06-11 | |||
| CN113318243A | 2021-08-31 | |||
| CN101401943A | 2009-04-08 | |||
| CN103055328A | 2013-04-24 | |||
| CN103394101A | 2013-11-20 | |||
| CN1673252A | 2005-09-28 | |||
| US5466439A | 1995-11-14 | |||
| US20120058054A1 | 2012-03-08 | |||
| CN111892645A | 2020-11-06 |
Other References:
ÜNALEROGLU C., B. ZÜMREOĞLU-KARAN,Ş. ÖZCAN,T. FIRAT: "Characterization and Magnetic Behavior of Cobalt(II) and Gadolinium(III) Polyacrylates", JOURNAL OF APPLIED POLYMER SCIENCE, JOHN WILEY & SONS, INC., US, vol. 56, no. 10, 6 June 1995 (1995-06-06), US , pages 1239 - 1243, XP055970963, ISSN: 0021-8995, DOI: 10.1002/app.1995.070561006
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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