Title:
GADOTERIDOL INTERMEDIATE AND METHOD FOR PREPARING GADOTERIDOL USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/143073
Kind Code:
A1
Abstract:
Disclosed are an intermediate for gadoteridol used as an MRI contrast agent, and a method for preparing gadoteridol using same. Provided, as a gadoteridol intermediate, is 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane, which is represented by chemical formula 1 in the description, or a hydrochloride thereof, which is represented by chemical formula 3 in the description.
Inventors:
LEE JAE YONG (KR)
LEE JONG SOO (KR)
KANG BYUNG KYU (KR)
LEE BYUONG WOO (KR)
LEE SANG OH (KR)
YUN DAE MYOUNG (KR)
BANG JAE HUN (KR)
SOHN KI YOUNG (KR)
LEE JONG SOO (KR)
KANG BYUNG KYU (KR)
LEE BYUONG WOO (KR)
LEE SANG OH (KR)
YUN DAE MYOUNG (KR)
BANG JAE HUN (KR)
SOHN KI YOUNG (KR)
Application Number:
PCT/KR2019/000483
Publication Date:
July 25, 2019
Filing Date:
January 11, 2019
Export Citation:
Assignee:
ENZYCHEM LIFESCIENCES CORP (KR)
International Classes:
C07D257/02; A61K49/06; A61K49/10
Foreign References:
| KR100269081B1 | 2000-10-16 | |||
| JP3471836B2 | 2003-12-02 | |||
| JP2002508755A | 2002-03-19 | |||
| JPH09268131A | 1997-10-14 |
Other References:
GLOGARD, C. ET AL.: "Synthesis and physicochemical characterisation of new amphophilic gadolinium DO3A complexes as contrast agents for MRI", JOURNAL OF THE CHEMICAL SOCIETY PERKIN TRANSACTIONS 2, vol. 2, no. 5, 2000, pages 1047 - 1052, XP001147817, doi:10.1039/a908979i
Attorney, Agent or Firm:
SHINWOO PATENT & LAW FIRM (KR)
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