Title:
Galantamine salts, method of producing it and nasal composition thereof
Document Type and Number:
WIPO Patent Application WO2005102275
Kind Code:
B1
Abstract:
Methods and compositions of the invention employ acethylcholinesterase (ACE) inhibitors to prevent and treat diseases and other disorders of the central nervous system (CNS), including Alzheimer's disease. ACE inhibitors are administered for targeted delivery to the CNS, for example by intranasal delivery. The methods and compositions of the present invention yield therapeutic concentrations of ACE inhibitors in a CNS tissue or compartment without the attendant disadvantages, risks and side effects of oral or injection delivery. Exemplary ACE inhibitors for use within the invention include galantamine and various salts and derivatives of galantamine. Carboxylate salts of galantamine (e.g., galantamine gluconate, galantamine lactate, galantamine citrate and galantamine glucarate) described herein exhibit a significant increase in solubility compared to other forms of galantamine, such as galantamine hydrobromide.
Inventors:
QUAY STEVEN C (US)
COSTANTINO HENRY R (US)
HOUSTON MICHAEL E JR (US)
LEONARD ALEXIS KAYS (US)
COSTANTINO HENRY R (US)
HOUSTON MICHAEL E JR (US)
LEONARD ALEXIS KAYS (US)
Application Number:
PCT/US2005/013776
Publication Date:
May 11, 2006
Filing Date:
April 22, 2005
Export Citation:
Assignee:
QUAY STEVEN C (US)
COSTANTINO HENRY R (US)
HOUSTON MICHAEL E JR (US)
LEONARD ALEXIS KAYS (US)
NASTECH PHARM CO (US)
COSTANTINO HENRY R (US)
HOUSTON MICHAEL E JR (US)
LEONARD ALEXIS KAYS (US)
NASTECH PHARM CO (US)
International Classes:
A61K9/00; A61K31/473; A61K31/48; A61K31/55; A61K31/724; A61K45/06; A61K47/42; C07D491/10; (IPC1-7): A61K9/00; A61K31/473; A61K47/42; C07D491/10
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