GD2-BASED CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF - BEIJING MEIKANG GENO IMMUNE BIOTECHNOLOGY CO LTD

Title:

GD2-BASED CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/020194

Kind Code:

A1

Abstract:

The present application relates to a GD2-based chimeric antigen receptor comprising an antigen-binding domain, a transmembrane domain, a costimulatory signaling domain, a CD3ζ signaling domain, and a self-destructive domain in tandem arrangement; wherein the antigen-binding domain binds to a tumor surface antigen, wherein the tumor surface antigen is GD2, and the antigen-binding domain is a single-chain antibody against the tumor surface antigen GD2, wherein the self-destructive domain is a caspase 9 domain.

More Like This:

JP2008521759	A fusion protein containing the BH3 domain sequence of the BH3-only protein
WO/1990/009195	CROSS-LINKED ANTIBODIES AND PROCESSES FOR THEIR PREPARATION
WO/2023/047129	IMMUNOGENIC FUSION PEPTIDES INCLUDING FC FRAGMENT AND A NON TOXIC B SUBUNIT OF AB5 TOXIN

Inventors:

LI YUCHEN (CN)

Application Number:

PCT/CN2019/097402

Publication Date:

January 30, 2020

Filing Date:

July 24, 2019

Export Citation:

Click for automatic bibliography generation Help

Assignee:

BEIJING MEIKANG GENO IMMUNE BIOTECHNOLOGY CO LTD (CN)

International Classes:

C07K19/00; A61K35/17; A61P35/00; C12N5/10; C12N15/867

Domestic Patent References:

WO2016187158A1

2016-11-24

Foreign References:

CN108948211A	2018-12-07
CN107106665A	2017-08-29

Other References: