Title:
GEL COMPOSITION FOR REMOVING RESIDUAL STONE FRAGMENTS AFTER LITHOTRIPSY
Document Type and Number:
WIPO Patent Application WO/2022/242533
Kind Code:
A1
Abstract:
A gel composition for improving the efficiency of calculus lithotripsy surgery of the urinary system and assisting in the removal of stone fragments in a kidney collection system. The gel composition comprises component A and component B, wherein component A contains fibrinogen and a fibrin stabilizing factor, and component B contains thrombin. In addition, Ca2+, plasminogen and a coloring agent are added to component A and/or component B. The gel composition may quickly form a plasminogen-containing fibrin gel having a degree of color recognition, and a certain toughness and plasticity in urine and normal saline environments, may adhere to and encapsulate stone fragments in the urine and saline environments, and is removed from the body by using negative pressure suction and/or a stone extraction basket. The gel composition is especially suitable for efficiently removing small stone fragments which remain after calculus lithotripsy and for which there is no effective method for removal at present, has good biosafety, and achieves a stone removal rate of more than 85% without any damage to the collection system and surgical instruments. In addition, the fibrin gel may be naturally dissolved in urine without the risk of urinary system obstruction.
Inventors:
ZHOU XIAOCHEN (CN)
KUANG RENRUI (CN)
XI HAIBO (CN)
YU YUE (CN)
DENG JUN (CN)
CHEN YUJUN (CN)
CHEN XINPENG (CN)
KUANG RENRUI (CN)
XI HAIBO (CN)
YU YUE (CN)
DENG JUN (CN)
CHEN YUJUN (CN)
CHEN XINPENG (CN)
Application Number:
PCT/CN2022/092370
Publication Date:
November 24, 2022
Filing Date:
May 12, 2022
Export Citation:
Assignee:
ZHOU XIAOCHEN (CN)
International Classes:
A61K9/06; A61B17/22; A61K38/36; A61K38/37; A61K38/48; A61P13/04; A61P41/00
Domestic Patent References:
| WO1981000516A1 | 1981-03-05 |
Foreign References:
| CN113332229A | 2021-09-03 | |||
| US20190274698A1 | 2019-09-12 | |||
| CN105283140A | 2016-01-27 |
Other References:
TAN, JIAN: "Kidney Stone Removal with Fibrin Mesh", GUO WAI YI XUE QING BAO = MEDICAL INFORMATION, XX, CN, no. 14, 31 December 1981 (1981-12-31), CN , pages 248, XP009541213, ISSN: 1003-0395
佟锦 (TONG, JIN): "经肾盂凝结取石术 (Non-official translation: Nephrolithotomy through the condensation of renal pelvis)", 国际外科学杂志 (INTERNATIONAL JOURNAL OF SURGERY), no. 6, 30 November 1975 (1975-11-30), ISSN: 1673-4203
戴植本: "纤维蛋白粘合剂的组成配制及临床应用 (Non-official translation: Composition and Clinical Application of Fibrin Adhesive)", 中国实用外科杂志 (CHINESE JOURNAL OF PRACTICAL SURGERY), vol. 7, no. 3, 25 March 1987 (1987-03-25), ISSN: 1005-2208
BORGES, R. ET AL.: "Coagulum Pyelolithotomy "Revisited" by Laparoscopy: Technique Modification", UROLOGY, vol. 6, no. 79, 30 June 2012 (2012-06-30), ISSN: 0090-4295
佟锦 (TONG, JIN): "经肾盂凝结取石术 (Non-official translation: Nephrolithotomy through the condensation of renal pelvis)", 国际外科学杂志 (INTERNATIONAL JOURNAL OF SURGERY), no. 6, 30 November 1975 (1975-11-30), ISSN: 1673-4203
戴植本: "纤维蛋白粘合剂的组成配制及临床应用 (Non-official translation: Composition and Clinical Application of Fibrin Adhesive)", 中国实用外科杂志 (CHINESE JOURNAL OF PRACTICAL SURGERY), vol. 7, no. 3, 25 March 1987 (1987-03-25), ISSN: 1005-2208
BORGES, R. ET AL.: "Coagulum Pyelolithotomy "Revisited" by Laparoscopy: Technique Modification", UROLOGY, vol. 6, no. 79, 30 June 2012 (2012-06-30), ISSN: 0090-4295
Attorney, Agent or Firm:
SHANGHAI FRONT LINE INTELLECTUAL PROPERTY AGENCY (CN)
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