Title:
GEL OF SODIUM HYALURONATE CROSS-LINKED BY POLYETHYLENE GLYCOL EPOXY DERIVATIVE FOR INJECTION AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/121510
Kind Code:
A1
Abstract:
A gel of sodium hyaluronate cross-linked by a polyethylene glycol epoxy derivative for injection and a preparation method thereof are provided. The polyethylene glycol epoxy derivative is preferably a compound having a single molecular weight, and a molecule of the compound includes a plurality of ether bonds, and has high water solubility, such that the compound is easily cross-linked with polysaccharides. In addition, since the number of repeating units of polyethylene glycol is more easily adjusted, the chain length thereof is more easily regulated. Therefore, the function of the sodium hyaluronate gel prepared by polyethylene glycol as a cross-linking agent is more easily regulated. The advantages of the cross-linked gel of sodium hyaluronate include low toxicity, low residue, low pushing force, good plasticity, good enzyme resistance, and long in-vivo time. A moderate inactivation process of the cross-linking agent is further disclosed. In the gel, unreacted epoxy groups can be hydrolyzed under a carbonate buffering system of pH 8-9, in order to effectively reduce the difficulty of removing impurities from the cross-linked gel of sodium hyaluronate, avoiding the use of toxic BDDE as a cross-linking agent in the art.
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Inventors:
WEI ZHEN (CN)
LIN MEINA (CN)
ZHAO XUAN (CN)
LIN MEINA (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2017/118542
Publication Date:
July 05, 2018
Filing Date:
December 26, 2017
Export Citation:
Assignee:
JENKEM TECH CO LTD BEIJING (CN)
International Classes:
C08G65/48; C08J3/075; C08L5/08; C08L71/02
Foreign References:
| CN106167549A | 2016-11-30 | |||
| CN103974722A | 2014-08-06 | |||
| CN106519072A | 2017-03-22 | |||
| CN103360633A | 2013-10-23 |
Other References:
TEODORESCU, MIRCEA ET AL.: "Novel Hydrogels from Diepoxy-Terminated Poly (Ethylene Glycol) s and Aliphatic Primary Diamines: Synthesis and Equilibrium Swelling Studies", POLYM. ADV. TECHNOL., vol. 20, no. 12, 9 January 2009 (2009-01-09), pages 907 - 915, XP055511398, ISSN: 1042-7147, Retrieved from the Internet
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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