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Title:
GENE CODING FOR CHIMERIC RECEPTOR FOR ANTI-ACETYLCHOLINE RECEPTOR AUTOANTIBODY
Document Type and Number:
WIPO Patent Application WO/2022/196719
Kind Code:
A1
Abstract:
The present invention provides: a chimeric receptor polypeptide which is useful in treatment of myasthenia gravis and in which an extracellular domain that includes an antigenic region linkable to an anti-human nicotinic acetylcholine receptor α1 sub-unit (nAChRα1) antibody, a cell transmembrane region, and an intracellular domain that includes an intracellular signal transduction region are disposed in this order from the N-terminus to the C-terminus (where the amino acid sequence of the antigenic region is that of SEQ ID NO: 2, or a region including an amino acid sequence in which one or more amino acids have been substituted, deleted, inserted, and/or added in the amino acid sequence of SEQ ID NO: 2); a polynucleotide which codes for the chimeric receptor polypeptide; and a cell which expresses the chimeric receptor polypeptide.

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Inventors:
YOSHIKIYO KAZUNORI (JP)
GOTO KAZUMICHI (JP)
TSUJIMOTO MAKI (JP)
NAGASAKI CHIKAKO (JP)
YOSHIDA SAYAKA (JP)
TAGAYA HIROAKI (JP)
Application Number:
PCT/JP2022/011820
Publication Date:
September 22, 2022
Filing Date:
March 16, 2022
Export Citation:
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Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/62; A61K35/15; A61K35/17; A61K35/545; A61K35/76; A61K39/395; A61K47/68; A61K48/00; A61P21/04; A61P43/00; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/0735; C12N5/078; C12N5/0783; C12N5/10; C12N15/12; C12N15/63; C12N15/867
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Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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