GENE DELIVERY TO ORGANS - UNIV JOHNS HOPKINS

Title:

GENE DELIVERY TO ORGANS

Document Type and Number:

WIPO Patent Application WO2004108087

Kind Code:

A3

Abstract:

Application of a virus with poloxamer alone onto atria results in diffuse epicardial gene transfer with negligible penetration into the myocardium. Progressive increases in protease concentration, however, allow transmural gene transfer. After protease exposure, echocardiographic left atrial diameter does not change. Left atrial ejection fraction decreases on post-operative day 3, but returns to baseline by day 7. At appropriate protease concentrations, tissue tensile strength is unaffected by the procedure. Transmural atrial gene transfer can be effected using this direct "painting" method.

Inventors:

DONAHUE J KEVIN (US)
MCDONALD AMY D (US)
KIKUCHI KAN (US)

Application Number:

PCT/US2004/017702

Publication Date:

January 26, 2006

Filing Date:

June 04, 2004

Export Citation:

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Assignee:

UNIV JOHNS HOPKINS (US)
DONAHUE J KEVIN (US)
MCDONALD AMY D (US)
KIKUCHI KAN (US)

International Classes:

A61K48/00; A61K; (IPC1-7): A61K31/70; A61K9/14; C12N15/63

Foreign References:

US6258791B1	2001-07-10
US6040295A	2000-03-21
US5292516A	1994-03-08
US6359054B1	2002-03-19

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