GENE EDITOR FOR DISEASE TREATMENT AND NUCLEIC ACID PHARMACEUTICAL COMPOSITION FOR ANTI-FIBROSIS INHIBITOR

Title:

GENE EDITOR FOR DISEASE TREATMENT AND NUCLEIC ACID PHARMACEUTICAL COMPOSITION FOR ANTI-FIBROSIS INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2024/088384

Kind Code:

A1

Abstract:

Provided in the present invention are a gene editor for disease treatment and a nucleic acid pharmaceutical composition for an anti-fibrosis inhibitor. Specifically, the pharmaceutical composition contains: (a) a first active ingredient, which is a gene editor for performing base editing on a target gene; and (b) a second active ingredient, which is an anti-fibrosis inhibitor. In the present invention, a nucleic acid sequence encoding the gene editor and the anti-fibrosis inhibitor is treated on a genetic disease by means of using a viral or non-viral vector system, so that a gene can be repaired while fibrosis signals in the micro-environment can be inhibited, thereby achieving a synergistic therapeutic effect.

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Inventors:

HE CHUNYAN (CN)
LI FENGPENG (CN)
XIAO GUANGYUAN (CN)

Application Number:

PCT/CN2023/127083

Publication Date:

May 02, 2024

Filing Date:

October 27, 2023

Export Citation:

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Assignee:

SUZHOU GENASSIST THERAPEUTICS CO LTD (CN)

International Classes:

A61K48/00; A61K39/395; A61P11/00; C07K14/47; C12N15/63

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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