Title:
GENE EXPRESSION DIRECTED BY A SUPER-PSA PROMOTER
Document Type and Number:
WIPO Patent Application WO2001032685
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for the delivery and expression of therapeutic genes for treating prostate and non-prostate tumors in a gene therapy setting with therapeutic genes driven by a super PSA promoter. This approach enhances the capability of increasing the size of therapeutic gene inserts and maintaining specificity and efficiency of genes expression. This form of gene therapy strategy can be applied either alone or in combination with other adjuvant therapies or used in combination with various gene therapy strategies to achieve the maximum effect in cancer treatment, and in normal and benign tissues to enhance therapeutic gains.
Inventors:
CHUNG LELAND W K (US)
YEUNG FAN (US)
KAO CHINGHAI (US)
TRAPMAN JAN (NL)
YEUNG FAN (US)
KAO CHINGHAI (US)
TRAPMAN JAN (NL)
Application Number:
PCT/US2000/029581
Publication Date:
October 04, 2001
Filing Date:
October 26, 2000
Export Citation:
Assignee:
UNIV VIRGINIA (US)
CHUNG LELAND W K (US)
YEUNG FAN (US)
KAO CHINGHAI (US)
TRAPMAN JAN (NL)
CHUNG LELAND W K (US)
YEUNG FAN (US)
KAO CHINGHAI (US)
TRAPMAN JAN (NL)
International Classes:
A61K31/711; A61K35/12; A61K48/00; A61P13/08; A61P35/00; A61P43/00; A01K67/027; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/02; G01N33/574; (IPC1-7): C07H21/02; C07H21/04; C12Q1/68; C12N15/63; C12N15/00; A01N43/04
Domestic Patent References:
| WO1998035031A1 | 1998-08-13 | |||
| WO1995019434A1 | 1995-07-20 |
Other References:
CLEUTJENS ET AL.: "An androgen response element in a Far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter", MOLECULAR ENDOCRINOLOGY, vol. 11, no. 2, February 1997 (1997-02-01), pages 148 - 161, XP002938259
PANG ET AL.: "Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen", CANCER RESEARCH, vol. 57, 1 February 1997 (1997-02-01), pages 495 - 499, XP002938260
PANG ET AL.: "Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen", CANCER RESEARCH, vol. 57, 1 February 1997 (1997-02-01), pages 495 - 499, XP002938260
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