Title:
GENE FAMILY WITH TRANSFORMATION MODULATING ACTIVITY
Document Type and Number:
WIPO Patent Application WO1999029906
Kind Code:
A3
Abstract:
pp32 is a member of a highly conserved family of differentiation-regulated nuclear proteins that is highly expressed in nearly all human prostatic adenocarcinomas of Gleason Grade >/=5. This contrasts with the low percentage of prostate tumors that express molecular alterations in proto-oncogenes or demonstrate tumor suppressor mutation or loss of heterozygosity. By analysis of specimens of human prostatic adenocarcinoma and paired adjacent normal prostate from three individual patients, the inventors have shown that normal prostate continues to express normal pp32, whereas three of three sets of RT-PCR-amplified transcripts from prostatic adenocarcinomas display multiple cancer-associated coding sequence changes. The cancer-associated sequence changes appear to be functionally significant. Normal pp32 exerts antineoplastic effects through suppression of transformation. In contrast, cancer-associated pp32 variants augment, rather than inhibit, transformation.
Inventors:
PASTERNACK GARY R (US)
KOCHEAVAR GERALD J (US)
BRODY JONATHAN R (US)
KADKOL SHRIHARI S (US)
KOCHEAVAR GERALD J (US)
BRODY JONATHAN R (US)
KADKOL SHRIHARI S (US)
Application Number:
PCT/US1998/026433
Publication Date:
August 26, 1999
Filing Date:
December 11, 1998
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
PASTERNACK GARY R (US)
KOCHEAVAR GERALD J (US)
BRODY JONATHAN R (US)
KADKOL SHRIHARI S (US)
PASTERNACK GARY R (US)
KOCHEAVAR GERALD J (US)
BRODY JONATHAN R (US)
KADKOL SHRIHARI S (US)
International Classes:
C07K14/47; C07K16/18; C12N1/15; C12N1/19; G01N33/50; C12N1/21; C12N5/10; C12N15/09; C12P21/08; C12Q1/68; C12Q1/6886; G01N33/15; G01N33/53; A61K38/00; (IPC1-7): C12Q1/68; C07K7/08; C07K16/32; C12N15/11; G01N33/574
Domestic Patent References:
| WO1994003594A1 | 1994-02-17 | |||
| WO1996010092A1 | 1996-04-04 |
Other References:
DATABASE EMBL(EMHUM) EMBL,Heidelberg; 3 April 1997 (1997-04-03), REBEL J.M.J. ET AL.: "Human pp32 pseudogene", XP002106402
DATABASE EMBL(EMHUM) EMBL, Heidelberg; 8 January 1998 (1998-01-08), KOCHEVAR G.J. ET AL.: "Homo sapiens candidate tumor suppressor pp32r1 gene", XP002106403
DATABASE EMBL(EMHUM) EMBL, Heidelberg; 8 January 1998 (1998-01-08), KOCHEVAR G.J. ET AL.: "Homo sapiens candidate tumor suppressor pp32r1 gene", XP002106403
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