Title:
GENE KNOCK-IN NON-HUMAN ANIMAL
Document Type and Number:
WIPO Patent Application WO/2014/042251
Kind Code:
A1
Abstract:
A non-human animal, characterized in that DNA, obtained when DNA encoding an hp7 sequence and DNA encoding a poly-A addition signal are attached to the 3' side of DNA encoding an arbitrary exogenous gene, is inserted into an identical reading frame of an arbitrary target gene present on the genome of the non-human animal.
Inventors:
JISHAGE KOICHI (JP)
UEDA OTOYA (JP)
UEDA OTOYA (JP)
Application Number:
PCT/JP2013/074882
Publication Date:
March 20, 2014
Filing Date:
September 13, 2013
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A01K67/027; C12P21/08; G01N33/15; G01N33/50; G01N33/68; C07K16/28; C07K16/46; C12N15/09
Domestic Patent References:
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Foreign References:
| JPH07194384A | 1995-08-01 | |||
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Other References:
SHIGEOKA TOSHIAKI ET AL.: "Evidence that the Upfl-related molecular motor scans the 3'-UTR to ensure mRNA integrity", NUCLEIC ACIDS RES., vol. 40, no. 14, 2012, pages 1 - 11, XP055241600
KOZAK MARILYN: "Circumstances and Mechanisms of Inhibition of Translation by Secondary Structure in Eucaryotic mRNAs", MOL. CELL. BIOL., vol. 9, no. 11, 1989, pages 5134 - 5142, XP055241602
YOSHIYUKI OSUGI ET AL.: "Pharmacological and clinical profile of humanized anti-human IL-6 receptor antibody (tocilizumab), a novel therapeutic drug for Castleman's disease", FOLIA PHARMACOLOGICA JAPONICA, vol. 126, 2005, pages 419 - 425, XP055241609
J. EXP. MED., vol. 182, no. 5, 1 November 1995 (1995-11-01), pages 1461 - 1468
PROC. NATL. ACAD. SCI. U.S.A., vol. 85, pages 836 - 840
MOL. CELL. BIOL., vol. 9, 1989, pages 5134 - 5142
NUCLEIC ACID RESEARCH, 2012
PROC. NATL. ACAD. SCI. USA., vol. 83, 1986, pages 9537 - 9541
KANATSU-SHINOHARA, M. ET AL., BIOL. REPROD., vol. 79, 2008, pages 1121 - 1128
CUI, X. ET AL., NAT. BIOTECHNOL., vol. 29, 2011, pages 64 - 67
LI, T. ET AL., NUCLEIC ACIDS RES., vol. 39, 2011, pages 6315 - 6325
YANG, H. ET AL., CELL, 2013
NIU, Y. ET AL., J. GENET. GENOMICS, vol. 35, 2008, pages 701 - 714
J. IMMUNOL., vol. 143, 1989, pages 2900 - 2906
IGAWA ET AL., NAT. BIOTECHNOL., vol. 28, 2010, pages 1203 - 1207
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495
"Antibody Production: Essential Techniques", 1997, WILEY
"Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
NATURE, vol. 362, 1992, pages 255 - 258
INTERN. REV. IMMUNOL, vol. 13, 1995, pages 65 - 93
J. MOL. BIOL, vol. 222, 1991, pages 581 - 597
NATURE GENETICS, vol. 15, 1997, pages 146 - 156
PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
NISHIMOTO N., BLOOD, vol. 112, 2008, pages 3959 - 3969
CYTOKINE, vol. 20, no. 6, 21 December 2002 (2002-12-21), pages 304 - 311
BLOOD, vol. 112, 2008, pages 3959 - 3969
YAGI T., ANAL BIOCHEM., vol. 214, 1993, pages 77 - 86
KOZAK MARILYN: "Circumstances and Mechanisms of Inhibition of Translation by Secondary Structure in Eucaryotic mRNAs", MOL. CELL. BIOL., vol. 9, no. 11, 1989, pages 5134 - 5142, XP055241602
YOSHIYUKI OSUGI ET AL.: "Pharmacological and clinical profile of humanized anti-human IL-6 receptor antibody (tocilizumab), a novel therapeutic drug for Castleman's disease", FOLIA PHARMACOLOGICA JAPONICA, vol. 126, 2005, pages 419 - 425, XP055241609
J. EXP. MED., vol. 182, no. 5, 1 November 1995 (1995-11-01), pages 1461 - 1468
PROC. NATL. ACAD. SCI. U.S.A., vol. 85, pages 836 - 840
MOL. CELL. BIOL., vol. 9, 1989, pages 5134 - 5142
NUCLEIC ACID RESEARCH, 2012
PROC. NATL. ACAD. SCI. USA., vol. 83, 1986, pages 9537 - 9541
KANATSU-SHINOHARA, M. ET AL., BIOL. REPROD., vol. 79, 2008, pages 1121 - 1128
CUI, X. ET AL., NAT. BIOTECHNOL., vol. 29, 2011, pages 64 - 67
LI, T. ET AL., NUCLEIC ACIDS RES., vol. 39, 2011, pages 6315 - 6325
YANG, H. ET AL., CELL, 2013
NIU, Y. ET AL., J. GENET. GENOMICS, vol. 35, 2008, pages 701 - 714
J. IMMUNOL., vol. 143, 1989, pages 2900 - 2906
IGAWA ET AL., NAT. BIOTECHNOL., vol. 28, 2010, pages 1203 - 1207
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495
"Antibody Production: Essential Techniques", 1997, WILEY
"Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
NATURE, vol. 362, 1992, pages 255 - 258
INTERN. REV. IMMUNOL, vol. 13, 1995, pages 65 - 93
J. MOL. BIOL, vol. 222, 1991, pages 581 - 597
NATURE GENETICS, vol. 15, 1997, pages 146 - 156
PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
NISHIMOTO N., BLOOD, vol. 112, 2008, pages 3959 - 3969
CYTOKINE, vol. 20, no. 6, 21 December 2002 (2002-12-21), pages 304 - 311
BLOOD, vol. 112, 2008, pages 3959 - 3969
YAGI T., ANAL BIOCHEM., vol. 214, 1993, pages 77 - 86
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
Patent business corporation cent Crest international patent firm (JP)
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