Title:
GENE THERAPY FOR HEMATOPOIETIC TUMOR BY PROLIFERATION-REGULATED VIRUS VECTOR CARRYING SURVIVIN PROMOTER
Document Type and Number:
WIPO Patent Application WO/2011/118819
Kind Code:
A1
Abstract:
Disclosed are: a novel dosage form of a proliferation-regulated virus vector, which enables the gene therapy for hematopoietic tumor using the vector; and a novel therapy means for hematopoietic tumor using the dosage form. Specifically disclosed are: a therapeutic agent for hematopoietic tumor, which comprises a proliferation-regulated virus vector carrying a nucleic acid that encodes at least one protein necessary for the replication of viruses and is under the regulation of a promoter for a gene capable of being expressed specifically in a hematopoietic tumor cell (preferably a survivin gene), and which is characterized by being administered systemically in such a form that a hematopoietic tumor cell is infected by the vector; and others.
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Inventors:
SUZUKI SHINSUKE (JP)
ARIMA NAOMICHI (JP)
KOSAI KEN-ICHIRO (JP)
ARIMA NAOMICHI (JP)
KOSAI KEN-ICHIRO (JP)
Application Number:
PCT/JP2011/057477
Publication Date:
September 29, 2011
Filing Date:
March 25, 2011
Export Citation:
Assignee:
SUZUKI SHINSUKE (JP)
ARIMA NAOMICHI (JP)
KOSAI KEN-ICHIRO (JP)
ARIMA NAOMICHI (JP)
KOSAI KEN-ICHIRO (JP)
International Classes:
A61K35/76; A61K35/761; A61K48/00; A61P35/00; A61P35/02; C12N15/09; C12N15/86
Domestic Patent References:
| WO2005115476A1 | 2005-12-08 | |||
| WO2003025190A1 | 2003-03-27 | |||
| WO2008013276A1 | 2008-01-31 |
Foreign References:
| JP2007525949A | 2007-09-13 |
Other References:
XIE M ET AL.: "A novel triple-regulated oncolytic adenovirus carrying PDCD5 gene exerts potent antitumor efficacy on common human leukemic cell lines", APOPTOSIS, vol. 14, no. 9, September 2009 (2009-09-01), pages 1086 - 1094, XP019727348, DOI: doi:10.1007/s10495-009-0373-3
WU YH ET AL.: "Reversal of drug resistance by silencing Survivin gene expression in acute myeloid leukemia cells", ACTA BIOCHIMICA POLONICA, vol. 55, no. 4, 2008, pages 673 - 680
CALDAS H ET AL.: "Survivin-driven therapy for leukemia", BLOOD, vol. 104, no. 11, 2004, pages 752A
KAMIZONO J ET AL.: "Survivin-Responsive Conditionally Replicating Adenovirus Exhibits Cancer-Specific and Efficient Viral Replication", CANCER RESEARCH, vol. 65, no. 12, 15 June 2005 (2005-06-15), pages 5284 - 5291, XP002997036, DOI: doi:10.1158/0008-5472.CAN-04-2657
RYOICHI HORIE ET AL.: "Ketsueki-kei Akusei Shuyo o Model to shita Zoshoku no Bunshi Kiko ni Motozuku Bunshi Hyoteki Idenshi Chiryo no Kisoteki Kento", KITASATO IGAKU, vol. 33, no. 1, 28 February 2003 (2003-02-28), pages 72 - 76
TAKURO WATANABE ET AL.: "Kumikae Adenovirus Vector o Mochiita Seijin T-saibosei Hakketsubyo no Saibo Tokuiteki, Bunshi Hyoteki Idenshi Chiryo no Kisoteki Kento", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, vol. 60, 26 September 2001 (2001-09-26), pages 615
MORI N ET AL.: "Expression of Survivin in HTLV-I-Infected T-Cell Lines and Primary ATL Cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 282, no. 5, 20 April 2001 (2001-04-20), pages 1110 - 1113
SUZUKI S ET AL.: "Induction of Cell Death in Adult T-Cell Leukemia Cell Lines by Survivin- Responsive Conditionally Replicating Adenoviruses", HAEMATOLOGICA -THE HEMATOLOGY JOURNAL, vol. 95, no. SUPP.2, June 2010 (2010-06-01), pages 169 - 170
WU YH ET AL.: "Reversal of drug resistance by silencing Survivin gene expression in acute myeloid leukemia cells", ACTA BIOCHIMICA POLONICA, vol. 55, no. 4, 2008, pages 673 - 680
CALDAS H ET AL.: "Survivin-driven therapy for leukemia", BLOOD, vol. 104, no. 11, 2004, pages 752A
KAMIZONO J ET AL.: "Survivin-Responsive Conditionally Replicating Adenovirus Exhibits Cancer-Specific and Efficient Viral Replication", CANCER RESEARCH, vol. 65, no. 12, 15 June 2005 (2005-06-15), pages 5284 - 5291, XP002997036, DOI: doi:10.1158/0008-5472.CAN-04-2657
RYOICHI HORIE ET AL.: "Ketsueki-kei Akusei Shuyo o Model to shita Zoshoku no Bunshi Kiko ni Motozuku Bunshi Hyoteki Idenshi Chiryo no Kisoteki Kento", KITASATO IGAKU, vol. 33, no. 1, 28 February 2003 (2003-02-28), pages 72 - 76
TAKURO WATANABE ET AL.: "Kumikae Adenovirus Vector o Mochiita Seijin T-saibosei Hakketsubyo no Saibo Tokuiteki, Bunshi Hyoteki Idenshi Chiryo no Kisoteki Kento", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, vol. 60, 26 September 2001 (2001-09-26), pages 615
MORI N ET AL.: "Expression of Survivin in HTLV-I-Infected T-Cell Lines and Primary ATL Cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 282, no. 5, 20 April 2001 (2001-04-20), pages 1110 - 1113
SUZUKI S ET AL.: "Induction of Cell Death in Adult T-Cell Leukemia Cell Lines by Survivin- Responsive Conditionally Replicating Adenoviruses", HAEMATOLOGICA -THE HEMATOLOGY JOURNAL, vol. 95, no. SUPP.2, June 2010 (2010-06-01), pages 169 - 170
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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