Title:
GENE THERAPY OF HIPPO SIGNALING IMPROVES HEART FUNCTION IN A CLINICALLY RELEVANT MODEL
Document Type and Number:
WIPO Patent Application WO/2024/006898
Kind Code:
A3
Abstract:
Embodiments of the disclosure include methods and compositions for improving heart function, including reducing the risk of arrhythmia in an individual in need thereof. In particular embodiments, an individual with a need for improved heart function and/or reduced risk of arrhythmia is provided an effective amount of a shRNA molecule that targets the Sav1 gene.
Inventors:
MARTIN JAMES F (US)
LEACH JOHN P (US)
LIU SHIJIE (US)
ZHANG SUI (US)
LEACH JOHN P (US)
LIU SHIJIE (US)
ZHANG SUI (US)
Application Number:
PCT/US2023/069359
Publication Date:
April 11, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
TEXAS HEART INST (US)
YAP THERAPEUTICS INC (US)
TEXAS HEART INST (US)
YAP THERAPEUTICS INC (US)
International Classes:
C12N15/113; A61K31/7088; A61P9/04; A61P9/10; A61K31/713; A61P9/00; C07H21/02
Attorney, Agent or Firm:
EDDY, Sarah D. (US)
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