Title:
GENERATION OF PROTEIN SEQUENCES USING MACHINE LEARNING TECHNIQUES
Document Type and Number:
WIPO Patent Application WO/2020/236839
Kind Code:
A3
Abstract:
Amino acid sequences of antibodies can be generated using a generative adversarial network that includes a first generating component that generates amino acid sequences of antibody light chains and a second generating component that generates amino acid sequences of antibody heavy chains. Amino acid sequences of antibodies can be produced by combining the respective amino acid sequences produced by the first generating component and the second generating component. The training of the first generating component and the second generating component can proceed at different rates. Additionally, the antibody amino acids produced by combining amino acid sequences from the first generating component and the second generating component may be evaluated according to complentarity-determining regions of the antibody amino acid sequences. Training datasets may be produced using amino acid sequences that correspond to antibodies have particular binding affinities with respect to molecules, such as binding affinity with major histocompatibility complex (MHC) molecules.
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Inventors:
AMIMEUR TILELI (US)
KETCHEM RANDAL ROBERT (US)
SHAVER JEREMY MARTIN (US)
CLARK RUTILIO H (US)
TAYLOR JOHN ALEX (US)
KETCHEM RANDAL ROBERT (US)
SHAVER JEREMY MARTIN (US)
CLARK RUTILIO H (US)
TAYLOR JOHN ALEX (US)
Application Number:
PCT/US2020/033646
Publication Date:
June 10, 2021
Filing Date:
May 19, 2020
Export Citation:
Assignee:
JUST EVOTEC BIOLOGICS INC (US)
International Classes:
A61K39/395; G16B20/00; C12Q1/6869; G01N33/53; G01N33/68; G16B40/00
Domestic Patent References:
| WO2005072112A2 | 2005-08-11 |
Foreign References:
| US20190018019A1 | 2019-01-17 |
Other References:
ANVITA GUPTA, JAMES ZOU: "Feedback GAN (FBGAN) for DNA: a Novel Feedback-Loop Architecture for Optimizing Protein Functions", ARXIV.ORG, 5 April 2018 (2018-04-05), pages 1 - 15, XP080867775
AMIMEUR TILELI, SHAVER JEREMY M., KETCHEM RANDAL R., TAYLOR J. ALEX, CLARK RUTILIO H., SMITH JOSH, VAN CITTERS DANIELLE, SISKA CHR: "Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks", 23 April 2020 (2020-04-23), pages 1 - 34, XP055824617, Retrieved from the Internet DOI: 10.1101/ 2020.04.12.024844
AMIMEUR TILELI, SHAVER JEREMY M., KETCHEM RANDAL R., TAYLOR J. ALEX, CLARK RUTILIO H., SMITH JOSH, VAN CITTERS DANIELLE, SISKA CHR: "Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks", 23 April 2020 (2020-04-23), pages 1 - 34, XP055824617, Retrieved from the Internet
Attorney, Agent or Firm:
PERDOK, Monique M. et al. (US)
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