Title:
GENETIC DETERMINANT FOR CHRONIC INFLAMMATORY DISEASE
Document Type and Number:
WIPO Patent Application WO2001071030
Kind Code:
A3
Abstract:
There is disclosed a method for determining susceptibility of a human subject to a chronic inflammatory disease which method comprises screening for the presence or absence in the genome of the human subject of one or more polymorphic variants of the MMP-3 gene. Also disclosed is a method for determining susceptibility of a human subject to a chronic inflammatory disease which method comprises screening for the presence or absence in the genome of the human subject of one or more polymorphic variants of the MMP-3 gene and determining the genotype of the subject at one or more further polymorphic loci associated with the said chronic inflammatory disease.
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Inventors:
SATSANGI JACK (GB)
WELSH KENNETH (GB)
HALDAR NEIL (GB)
CHAPMAN ROGER (GB)
WELSH KENNETH (GB)
HALDAR NEIL (GB)
CHAPMAN ROGER (GB)
Application Number:
PCT/GB2001/001267
Publication Date:
April 24, 2003
Filing Date:
March 22, 2001
Export Citation:
Assignee:
ISIS INNOVATION (GB)
OXFORD RADCLIFFE HOSPITAL NHS (GB)
SATSANGI JACK (GB)
WELSH KENNETH (GB)
HALDAR NEIL (GB)
CHAPMAN ROGER (GB)
OXFORD RADCLIFFE HOSPITAL NHS (GB)
SATSANGI JACK (GB)
WELSH KENNETH (GB)
HALDAR NEIL (GB)
CHAPMAN ROGER (GB)
International Classes:
C12Q1/68; C12Q1/6883; (IPC1-7): C12Q1/68
Other References:
TERASHIMA M ET AL.: "Stromelysin promoter 5A/6A polymorphism is associated with acute myocardial infarction", CIRCULATION, vol. 99, 1999, pages 2717 - 2719, XP002212577
YE S ET AL: "PROGRESSION OF CORONARY ATHEROSCLEROSIS IS ASSOCIATED WITH A COMMON GENETIC VARIANT OF THE HUMAN STROMELYSIN-1 PROMOTER WHICH RESULTS IN REDUCED GENE EXPRESSION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 22, 31 May 1996 (1996-05-31), pages 13055 - 13060, XP002915705, ISSN: 0021-9258
BUNCE M ET AL: "RAPID HLA-DQB TYPING BY EIGHT POLYMERASE CHAN REACTION AMPLICATIONSWITH SEQUENCE-SPECIFIC PRIMERS (PCR-SSP)", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 37, no. 4, 1993, pages 201 - 206, XP000972171, ISSN: 0198-8859
SATSANGI J ET AL.: "A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis", GASTROENTEROLOGY, vol. 121, January 2001 (2001-01-01), pages 124 - 130, XP001074333
SATSANGI J ET AL.: "A regulatory polymorphism of the stromelysin gene (MMP-3) strongly influences susceptibility to primary sclerosing cholangitis (PSC) and prgression to portal hypertension", GASTROENTEROLOGY, vol. 118, no. 4Pt1, April 2000 (2000-04-01), pages 3645, XP002212578
YE S ET AL: "PROGRESSION OF CORONARY ATHEROSCLEROSIS IS ASSOCIATED WITH A COMMON GENETIC VARIANT OF THE HUMAN STROMELYSIN-1 PROMOTER WHICH RESULTS IN REDUCED GENE EXPRESSION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 22, 31 May 1996 (1996-05-31), pages 13055 - 13060, XP002915705, ISSN: 0021-9258
BUNCE M ET AL: "RAPID HLA-DQB TYPING BY EIGHT POLYMERASE CHAN REACTION AMPLICATIONSWITH SEQUENCE-SPECIFIC PRIMERS (PCR-SSP)", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 37, no. 4, 1993, pages 201 - 206, XP000972171, ISSN: 0198-8859
SATSANGI J ET AL.: "A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis", GASTROENTEROLOGY, vol. 121, January 2001 (2001-01-01), pages 124 - 130, XP001074333
SATSANGI J ET AL.: "A regulatory polymorphism of the stromelysin gene (MMP-3) strongly influences susceptibility to primary sclerosing cholangitis (PSC) and prgression to portal hypertension", GASTROENTEROLOGY, vol. 118, no. 4Pt1, April 2000 (2000-04-01), pages 3645, XP002212578
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