GENETIC MARKER FOR DETERMINING PATHOGENICITY OF STREPTOCOCCUS INIAE AND KIT FOR EXAMINING DETERMINANT MARKERS OF PATHOGENICITY BY USING PEPTIDE NUCLEIC ACID

WIPO Patent Application WO/2016/098953

A1

The present invention relates to a probe for determining a genotype of Steptococcus iniae, the probe being capable of hybridizing, under strict conditions, with a sequence fragment containing a single nucleotide polymorphism variation of T368C or T385G in the cpsD sequence, which is represented by SEQ ID NO: 1, of Streptococcus iniae and, more particularly, to a kit which allows each genotype influencing pathogenicity to have different melting temperature by using a peptide nucleic acid (PNA) having an excellent binding ability to DNA, thereby enabling a simple, rapid, and accurate determination of the pathogenicity of S. iniae.

KIM MYOUNG SUG (KR)
CHOI HYE SUNG (KR)
JUNG SUNG-HEE (KR)
HAN HYUN-JA (KR)
DO JEUNG-WAN (KR)

PCT/KR2015/002344

June 23, 2016

March 11, 2015

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NFRDI (KR)

C12Q1/68

US20140121287A1	2014-05-01
US20050106578A1	2005-05-19

MILLARD, C. M. ET AL.: "Evolution of the Capsular Operon of Streptococcus Iniae in Response to Vaccination", APPL. ENVIRON MICROBIOL., vol. 78, no. 23, 2012, pages 8219 - 8226
DATABASE Genbank [O] 5 November 2012 (2012-11-05), Database accession no. JX164245
LOCKE, JB. ET AL.: "Streptococcus Iniae Capsule Impairs Phagocytic Clearance and Contributes to Virulence in Fish", JOURNAL OF BACTERIOLOGY, vol. 189, no. 4, February 2007 (2007-02-01), pages 1279 - 1287

LEE, Cheo Young et al. (KR)
이처영 (KR)

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