Title:
GENETIC SWITCH
Document Type and Number:
WIPO Patent Application WO2001029231
Kind Code:
A3
Abstract:
The invention provides nucleic acid molecules that are useful in genetic manipulations of living systems. These molecules may be used to create transgenic animal systems that facilitate the study of the physiological role played in a living system by genes and the proteins that they encode.
Inventors:
STEWART ADRIAN FRANCIS (DE)
Application Number:
PCT/IB2000/001624
Publication Date:
November 01, 2001
Filing Date:
October 18, 2000
Export Citation:
Assignee:
EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE)
STEWART ADRIAN FRANCIS (DE)
STEWART ADRIAN FRANCIS (DE)
International Classes:
C12N9/00; C12N15/63; C12N15/85; C12N15/90; (IPC1-7): C12N15/62; A01K67/027; C12N9/00; C12N15/00; C12N15/10; C12N15/85; C12N15/90
Domestic Patent References:
| WO1995000555A1 | 1995-01-05 | |||
| WO1999011807A1 | 1999-03-11 |
Other References:
ROSSI F ET AL: "EXCISION OF ETS BY AN INDUCIBLE SITE-SPECIFIC RECOMBINASE CAUSES DIFFERENTIATION OF MYB-ETS-TRANSFORMED HEMATOPOIETIC PROGENITORS", CURRENT BIOLOGY,GB,CURRENT SCIENCE,, vol. 6, no. 7, 1 July 1996 (1996-07-01), pages 866 - 872, XP000617923, ISSN: 0960-9822
ROSSANT, J. & MCMAHON, A.: ""Cre"-ating mouse mutants -a meeting review on conditional mouse genetics", GENES & DEVELOPMENT, vol. 13, 15 January 1999 (1999-01-15), pages 142 - 145, XP001004604
SCHWENK FRIEDER ET AL: "Temporally and spatially regulated somatic mutagenesis in mice", NUCLEIC ACIDS RESEARCH,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 26, no. 6, 15 March 1998 (1998-03-15), pages 1427 - 1432, XP002154789, ISSN: 0305-1048
MEYERS, E.N. ET AL.: "An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination", NATURE GENETICS, vol. 18, 18 February 1998 (1998-02-18), XP002919952
ROSSANT, J. & MCMAHON, A.: ""Cre"-ating mouse mutants -a meeting review on conditional mouse genetics", GENES & DEVELOPMENT, vol. 13, 15 January 1999 (1999-01-15), pages 142 - 145, XP001004604
SCHWENK FRIEDER ET AL: "Temporally and spatially regulated somatic mutagenesis in mice", NUCLEIC ACIDS RESEARCH,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 26, no. 6, 15 March 1998 (1998-03-15), pages 1427 - 1432, XP002154789, ISSN: 0305-1048
MEYERS, E.N. ET AL.: "An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination", NATURE GENETICS, vol. 18, 18 February 1998 (1998-02-18), XP002919952
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