Title:
GENETICALLY MODIFIED MICROORGANISM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/093883
Kind Code:
A1
Abstract:
Disclosed are a genetically modified microorganism and the use thereof. The genetically modified microorganism expresses at least one, two or three exogenous genes (AMUC_1100 polypeptide, IL-10 and/or IL-22). The genetically modified microorganism can still stably survive after integrating exogenous target genes therein; and efficiently expresses and secretes proteins or polypeptides encoded by the exogenous genes in the intestinal tract, and the expressed and secreted proteins or polypeptide encoded by the exogenous genes can still have good activity. Therefore, the genetically modified microorganism is used for treating inflammatory diseases or autoimmune diseases (such as enteritis and arthritis).
Inventors:
GUO YUQI (CN)
YANG GUOXUE (CN)
XIANG BIN (CN)
YANG GUOXUE (CN)
XIANG BIN (CN)
Application Number:
PCT/CN2022/134672
Publication Date:
June 01, 2023
Filing Date:
November 28, 2022
Export Citation:
Assignee:
COMMBIO THERAPEUTICS CO LTD (CN)
International Classes:
A61K35/66; A61K35/38; A61K35/741; A61P37/00
Domestic Patent References:
| WO2021127235A1 | 2021-06-24 |
Foreign References:
| CN110709093A | 2020-01-17 | |||
| CN113413466A | 2021-09-21 | |||
| CN110950937A | 2020-04-03 | |||
| CN110698547A | 2020-01-17 |
Other References:
GU ZHENYANG, PEI WENLONG, SHEN YONGHUA, WANG LIJUAN, ZHU JUN, ZHANG YI, FAN SHENGXIAN, WU QIAN, LI LEI, ZHANG ZHAN: "Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 12, no. 20, 19 October 2021 (2021-10-19), GB , pages 10184 - 10195, XP093068737, ISSN: 2042-6496, DOI: 10.1039/D1FO02172A
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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