Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
Document Type and Number:
WIPO Patent Application WO/2022/222958
Kind Code:
A1
Abstract:
Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CSF1R and/or a human or chimeric (e.g., humanized) CSF 1, and methods of use thereof.
Inventors:
LV RUILI (CN)
ZHANG SHUJIN (CN)
ZHAO SUMAN (CN)
LIU CHONGHUI (CN)
ZHANG SHUJIN (CN)
ZHAO SUMAN (CN)
LIU CHONGHUI (CN)
Application Number:
PCT/CN2022/087916
Publication Date:
October 27, 2022
Filing Date:
April 20, 2022
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
C12N15/85; A01K67/027; A61K49/00; C12N5/10; C12N15/62
Domestic Patent References:
| WO2019199799A1 | 2019-10-17 |
Foreign References:
| CN113046390A | 2021-06-29 | |||
| CN111073907A | 2020-04-28 | |||
| CN102725400A | 2012-10-10 | |||
| CN105861553A | 2016-08-17 | |||
| CN108782459A | 2018-11-13 | |||
| CN110740641A | 2020-01-31 |
Other References:
GRELLIER BENOÎT, LE POGAM FABRICE, VITORINO MARC, STARCK JEAN-PHILIPPE, GEIST MICHEL, DUONG VANESSA, HAEGEL HÉLÈNE, MENGUY THIERRY: "3D modeling and characterization of the human CD115 monoclonal antibody H27K15 epitope and design of a chimeric CD115 target", MABS, LANDES BIOSCIENCE, US, vol. 6, no. 2, 1 March 2014 (2014-03-01), US , pages 533 - 546, XP055979390, ISSN: 1942-0870, DOI: 10.4161/mabs.27736
ANTHONY RONGVAUX, TIM WILLINGER, JAN MARTINEK, TILL STROWIG, SOFIA V GEARTY, LINO L TEICHMANN, YASUYUKI SAITO, FLORENTINA MARCHES,: "Development and function of human innate immune cells in a humanized mouse model", NATURE BIOTECHNOLOGY, GALE GROUP INC., XP055112690, ISSN: 10870156, DOI: 10.1038/nbt.2858
Y. LI, Q. CHEN, D. ZHENG, L. YIN, Y. H. CHIONH, L. H. WONG, S. Q. TAN, T. C. TAN, J. K. Y. CHAN, S. ALONSO, P. C. DEDON, B. LIM, J: "Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF in Humanized Mice", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 191, no. 6, 15 September 2013 (2013-09-15), pages 3192 - 3199, XP055166814, ISSN: 00221767, DOI: 10.4049/jimmunol.1300742
C. RATHINAM, W. T. POUEYMIROU, J. ROJAS, A. J. MURPHY, D. M. VALENZUELA, G. D. YANCOPOULOS, A. RONGVAUX, E. E. EYNON, M. G. MANZ, : "Efficient differentiation and function of human macrophages in humanized CSF-1 mice", BLOOD, vol. 118, no. 11, 15 September 2011 (2011-09-15), pages 3119 - 3128, XP055112602, ISSN: 00064971, DOI: 10.1182/blood-2010-12-326926
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 isoform 1 precursor [Mus musculus]", XP055979405
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 isoform 1 precursor [Mus musculus]", XP055979405
DATABASE Genbank NCBI; . : "Mus musculus targeted KO-first， conditional ready， lacZ-tagged mutant allele Csf1:tm1a(KOMP)Wtsi； transgenic", XP055979413
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 receptor precursor [Mus musculus]", XP055979418
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 receptor isoform a precursor [Homo sapiens]", XP055979542
DATABASE GenBank NCBI; . : "Mus musculus targeted KO-first， conditional ready， lacZ-tagged mutant allele Csf1r:tm1a(KOMP)Wtsi； transgenic", XP055979544
ANTHONY RONGVAUX, TIM WILLINGER, JAN MARTINEK, TILL STROWIG, SOFIA V GEARTY, LINO L TEICHMANN, YASUYUKI SAITO, FLORENTINA MARCHES,: "Development and function of human innate immune cells in a humanized mouse model", NATURE BIOTECHNOLOGY, GALE GROUP INC., XP055112690, ISSN: 10870156, DOI: 10.1038/nbt.2858
Y. LI, Q. CHEN, D. ZHENG, L. YIN, Y. H. CHIONH, L. H. WONG, S. Q. TAN, T. C. TAN, J. K. Y. CHAN, S. ALONSO, P. C. DEDON, B. LIM, J: "Induction of Functional Human Macrophages from Bone Marrow Promonocytes by M-CSF in Humanized Mice", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 191, no. 6, 15 September 2013 (2013-09-15), pages 3192 - 3199, XP055166814, ISSN: 00221767, DOI: 10.4049/jimmunol.1300742
C. RATHINAM, W. T. POUEYMIROU, J. ROJAS, A. J. MURPHY, D. M. VALENZUELA, G. D. YANCOPOULOS, A. RONGVAUX, E. E. EYNON, M. G. MANZ, : "Efficient differentiation and function of human macrophages in humanized CSF-1 mice", BLOOD, vol. 118, no. 11, 15 September 2011 (2011-09-15), pages 3119 - 3128, XP055112602, ISSN: 00064971, DOI: 10.1182/blood-2010-12-326926
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 isoform 1 precursor [Mus musculus]", XP055979405
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 isoform 1 precursor [Mus musculus]", XP055979405
DATABASE Genbank NCBI; . : "Mus musculus targeted KO-first， conditional ready， lacZ-tagged mutant allele Csf1:tm1a(KOMP)Wtsi； transgenic", XP055979413
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 receptor precursor [Mus musculus]", XP055979418
DATABASE GenBank NCBI; . : "macrophage colony-stimulating factor 1 receptor isoform a precursor [Homo sapiens]", XP055979542
DATABASE GenBank NCBI; . : "Mus musculus targeted KO-first， conditional ready， lacZ-tagged mutant allele Csf1r:tm1a(KOMP)Wtsi； transgenic", XP055979544
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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