Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD98HC
Document Type and Number:
WIPO Patent Application WO/2023/109956
Kind Code:
A1
Abstract:
Provided are genetically modified non-human animals that express a human or chimeric (e.g.,humanized) CD98HC, and methods of use thereof.
Inventors:
LV RUILI (CN)
SHEN ZHIYUAN (CN)
LI CHONG (CN)
SHEN ZHIYUAN (CN)
LI CHONG (CN)
Application Number:
PCT/CN2022/139671
Publication Date:
June 22, 2023
Filing Date:
December 16, 2022
Export Citation:
Assignee:
BIOCYTOGEN JIANGSU CO LTD (CN)
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
C12N15/85; A01K67/027; A61K39/395; C07K14/715; C12N15/12
Domestic Patent References:
| WO2013078377A1 | 2013-05-30 | |||
| WO2019072241A1 | 2019-04-18 |
Foreign References:
| CN110495425A | 2019-11-26 | |||
| CN112430621A | 2021-03-02 | |||
| CN113461802A | 2021-10-01 | |||
| US20110280884A1 | 2011-11-17 |
Other References:
FERAL,C.C.ET AL: "CD98hc (SLC3A2) mediates integrin signaling.", PNAS. VOL 102, NO 2, 11 January 2005 (2005-01-11), pages 355 - 360, XP002667312, DOI: 10.1073/PNAS.0404852102
CANTOR JOSEPH, BROWNE CECILLE D, RUPPERT RAPHAEL, FÉRAL CHLOÉ C, FÄSSLER REINHARD, RICKERT ROBERT C, GINSBERG MARK H: "CD98hc facilitates B cell proliferation and adaptive humoral immunity", NATURE IMMULOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 10, no. 4, 1 April 2009 (2009-04-01), New York , pages 412 - 419, XP093071505, ISSN: 1529-2908, DOI: 10.1038/ni.1712
CANTOR JOSEPH, BROWNE CECILLE D, RUPPERT RAPHAEL, FÉRAL CHLOÉ C, FÄSSLER REINHARD, RICKERT ROBERT C, GINSBERG MARK H: "CD98hc facilitates B cell proliferation and adaptive humoral immunity", NATURE IMMULOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 10, no. 4, 1 April 2009 (2009-04-01), New York , pages 412 - 419, XP093071505, ISSN: 1529-2908, DOI: 10.1038/ni.1712
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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