Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
Document Type and Number:
WIPO Patent Application WO/2023/226987
Kind Code:
A1
Abstract:
The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL2RG, IL2RB, IL15RA, and/or IL15, and methods of use thereof.
Inventors:
SHANG CHENGZHANG (CN)
WANG LINLIN (CN)
ZHAO SUMAN (CN)
YUAN JIANGFENG (CN)
WANG LINLIN (CN)
ZHAO SUMAN (CN)
YUAN JIANGFENG (CN)
Application Number:
PCT/CN2023/095823
Publication Date:
November 30, 2023
Filing Date:
May 23, 2023
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
C12N15/85; A01K67/027; A61K49/00; C07K14/54; C07K14/715; C12N15/12; C12N15/24
Domestic Patent References:
| WO2021027737A1 | 2021-02-18 | |||
| WO2020135518A1 | 2020-07-02 |
Foreign References:
| CN116479050A | 2023-07-25 | |||
| US5510259A | 1996-04-23 | |||
| CN113264996A | 2021-08-17 | |||
| CN111118019A | 2020-05-08 |
Other References:
DATABASE Protein 26 July 2016 (2016-07-26), ANONYMOUS : "interleukin 2 receptor, gamma chain, isoform CRA_a [Mus musculus] ", XP093112606, retrieved from NCBI Database accession no. EDL14151.1
DATABASE Protein 31 August 2016 (2016-08-31), ANONYMOUS : "Sequence 22 from patent US 9228208", XP093112607, retrieved from NCBI Database accession no. AOH76624.1
DATABASE Protein 3 September 2003 (2003-09-03), ANONYMOUS : "Sequence 4 from patent US 5198359 ", XP093112608, retrieved from NCBI Database accession no. AAQ69340.1
DATABASE Protein 17 October 2001 (2001-10-17), ANONYMOUS : "Sequence 2 from patent US 6281193", XP093112609, retrieved from NCBI Database accession no. AAE80151.1
DATABASE Protein 7 February 1997 (1997-02-07), ANONYMOUS : "Sequence 2 from patent US 5591630", XP093112611, retrieved from NCBI Database accession no. AAB45608.1
DATABASE Protein 4 August 2004 (2004-08-04), ANONYMOUS : "Interleukin 15 receptor, alpha, isoform 1 precursor [Homo sapiens]", XP093112614, retrieved from NCBI Database accession no. AAH74726.1
DATABASE Protein 26 July 2016 (2016-07-26), ANONYMOUS : "interleukin 15, isoform CRA_a, partial [Mus musculus] ", XP093112615, retrieved from NCBI Database accession no. EDL10891.1
DATABASE Protein 31 August 2016 (2016-08-31), ANONYMOUS : "Sequence 22 from patent US 9228208", XP093112607, retrieved from NCBI Database accession no. AOH76624.1
DATABASE Protein 3 September 2003 (2003-09-03), ANONYMOUS : "Sequence 4 from patent US 5198359 ", XP093112608, retrieved from NCBI Database accession no. AAQ69340.1
DATABASE Protein 17 October 2001 (2001-10-17), ANONYMOUS : "Sequence 2 from patent US 6281193", XP093112609, retrieved from NCBI Database accession no. AAE80151.1
DATABASE Protein 7 February 1997 (1997-02-07), ANONYMOUS : "Sequence 2 from patent US 5591630", XP093112611, retrieved from NCBI Database accession no. AAB45608.1
DATABASE Protein 4 August 2004 (2004-08-04), ANONYMOUS : "Interleukin 15 receptor, alpha, isoform 1 precursor [Homo sapiens]", XP093112614, retrieved from NCBI Database accession no. AAH74726.1
DATABASE Protein 26 July 2016 (2016-07-26), ANONYMOUS : "interleukin 15, isoform CRA_a, partial [Mus musculus] ", XP093112615, retrieved from NCBI Database accession no. EDL10891.1
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