Title:
GENOMIC INSULATOR ELEMENT EXHIBITING ENHANCER BLOCKING ACTIVITIES IN LYMPHOCYTES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/231192
Kind Code:
A3
Abstract:
A construct including a genomic insulator element that exhibits strong enhancer blocking activities in T lymphocytes is provided as are host cells, pharmaceutical compositions and methods of using the construct in the treatment of disease, in particular a disease to be treated with a retroviral vector-modified T lymphocyte.
Inventors:
ZHOU SHENG (US)
SORRENTINO BRIAN (US)
CHENG YONG (US)
SORRENTINO BRIAN (US)
CHENG YONG (US)
Application Number:
PCT/US2021/031210
Publication Date:
August 04, 2022
Filing Date:
May 07, 2021
Export Citation:
Assignee:
ST JUDE CHILDRENS RES HOSPITAL INC (US)
International Classes:
C12N15/86; C12N15/113
Foreign References:
| US20170175136A1 | 2017-06-22 | |||
| US20160032318A1 | 2016-02-04 | |||
| US20190309291A1 | 2019-10-10 |
Attorney, Agent or Firm:
LICATA, Jane Massey et al. (US)
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