Title:
GIBBERELLIN-LIKE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION, USES AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/184772
Kind Code:
A1
Abstract:
The present invention discloses a gibberellin-like compound, a preparation method therefor, a pharmaceutical composition, uses and an intermediate thereof, wherein the gibberellin-like compound shown in formula (I) has relatively good in-vitro antitumor and cytotoxic activity, and has particularly remarkable in-vitro cytotoxic activity against breast cancer cells or colon cancer cells. (I)
Inventors:
ZHANG HONGBIN (CN)
WU MINGJIANG (CN)
LI YAN (CN)
HE YANPING (CN)
CHEN JINGBO (CN)
YANG XIAODONG (CN)
CHEN WEN (CN)
GONG YAXIAO (CN)
WU MINGJIANG (CN)
LI YAN (CN)
HE YANPING (CN)
CHEN JINGBO (CN)
YANG XIAODONG (CN)
CHEN WEN (CN)
GONG YAXIAO (CN)
Application Number:
PCT/CN2019/078805
Publication Date:
October 03, 2019
Filing Date:
March 20, 2019
Export Citation:
Assignee:
UNIV YUNNAN (CN)
KUNMING INST BOTANY CAS (CN)
KUNMING INST BOTANY CAS (CN)
International Classes:
C07D249/06; A61K31/122; A61K31/4192; A61P35/00; C07C49/747; C07C247/10
Foreign References:
| CN102108075A | 2011-06-29 | |||
| CN101068764A | 2007-11-07 | |||
| CN1560044A | 2005-01-05 |
Other References:
WU, MINGJIANG ET AL.: "Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1, 2, 3-triazole pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18 May 2018 (2018-05-18), ISSN: 0960-894X
ANNAND, J. R.: "Synthesis and biological evaluation of pharbinilic Chemi- cal Communications", CHEMICAL COMMUNICATIONS, 21 April 2015 (2015-04-21), XP055639943, ISSN: 1359-7345
ANNAND, J. R.: "Synthesis and biological evaluation of pharbinilic Chemi- cal Communications", CHEMICAL COMMUNICATIONS, 21 April 2015 (2015-04-21), XP055639943, ISSN: 1359-7345
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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