GLAUCOCALYXIN A DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF - SUZHOU PHARMAVAN CANCER RES CENTER CO LTD

Title:

GLAUCOCALYXIN A DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/150207

Kind Code:

A1

Abstract:

Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fighting autoimmune diseases and tumors, e.g. difficult-to-treat diseases such as lupus erythematosus, psoriasis, and triple-negative breast cancer.

Inventors:

LI YUNSEN (CN)
CHEN ZIJUN (CN)
DENG SHIPING (CN)
FENG HAIMEI (CN)
WEI ZHONGYUAN (CN)
LI YONG (CN)
LIU QIAN (CN)
CHEN XIANG (CN)

Application Number:

PCT/CN2015/097692

Publication Date:

September 29, 2016

Filing Date:

December 17, 2015

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Assignee:

SUZHOU PHARMAVAN CANCER RES CENTER CO LTD (CN)

International Classes:

C07C225/12; A61P35/00; A61P37/02; C07C221/00; C07C237/30; C07D207/00; C07D233/60; C07D295/116; C07D473/18

Foreign References:

CN104817464A	2015-08-05
CN104887652A	2015-09-09
CN104761460A	2015-07-08
CN103601641A	2014-02-26
CN101993370A	2011-03-30

Other References:

J. YANG ET AL.: "Synthesis and Biological Evaluation of Glaucocalyxin A Derivatives as Potential Anticancer Agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 26, 21 August 2014 (2014-08-21), pages 235 - 241, XP029048580

Attorney, Agent or Firm:

BEYOND ATTORNEYS AT LAW (CN)
北京品源专利代理有限公司 (CN)

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