Title:
GLAUCOMA THERAPEUTICS AND DIAGNOSTICS
Document Type and Number:
WIPO Patent Application WO1999051779
Kind Code:
A3
Abstract:
Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.
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Inventors:
STONE EDWIN M
SHEFFIELD VAL C
ALWARD WALLACE L M
FINGERT JOHN
SHEFFIELD VAL C
ALWARD WALLACE L M
FINGERT JOHN
Application Number:
PCT/US1999/007671
Publication Date:
December 29, 1999
Filing Date:
April 07, 1999
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
International Classes:
C12N15/09; C07K14/47; C12N5/02; C12Q1/68; C12Q1/6883; A61K38/00; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO1996014411A1 | 1996-05-17 | |||
| WO1998032850A1 | 1998-07-30 | |||
| WO1998020131A1 | 1998-05-14 |
Other References:
STONE E.M. ET AL.: "Identification of a gene that causes primary open angle glaucoma", SCIENCE, vol. 275, 1997, US, pages 668 - 670, XP002049424
KUBOTA R. ET AL.: "Genomic organisation of the human myocilin gene (MYOC) responsible for primary open angle glaucoma", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 242, 1998, us, pages 396 - 400, XP002120488
KUBOTA R. ET AL.: "A novel myosin-like protein (myocilin) expressed in the conncting cilium of th ephotoreceptor: molecular cloning, tissue expression, and chromosomal mapping", GENOMICS, vol. 41, no. 3, 1 May 1997 (1997-05-01), US, pages 360 - 369, XP002120489
W.L.M. ALWARD ET AL.: "Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 338, 9 April 1998 (1998-04-09), US, pages 1022 - 1027, XP002120490
KUBOTA R. ET AL.: "Genomic organisation of the human myocilin gene (MYOC) responsible for primary open angle glaucoma", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 242, 1998, us, pages 396 - 400, XP002120488
KUBOTA R. ET AL.: "A novel myosin-like protein (myocilin) expressed in the conncting cilium of th ephotoreceptor: molecular cloning, tissue expression, and chromosomal mapping", GENOMICS, vol. 41, no. 3, 1 May 1997 (1997-05-01), US, pages 360 - 369, XP002120489
W.L.M. ALWARD ET AL.: "Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 338, 9 April 1998 (1998-04-09), US, pages 1022 - 1027, XP002120490
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