Title:
GLIOMA DIAGNOSTIC MARKER, DETERMINATION METHOD, DIAGNOSTIC METHOD, GLYCAN MARKER DETECTION METHOD, AND GLYCAN MARKER
Document Type and Number:
WIPO Patent Application WO/2016/021729
Kind Code:
A1
Abstract:
This glioma diagnostic marker is formed from at least one glycan selected from the group consisting of: a sialylated complex N-linked glycan; a neutral bisecting N-linked glycan; a neutral biantennary complex N-linked glycan having two fucose units; a neutral hybrid N-linked glycan having a fucose unit; a neutral bisecting N-linked glycan having a plurality of fucose units; a monoantennary glycan; a whole N-linked glycan; a whole GSL-glycan; a fucosylated (n)Lc-series GSL-glycan; a core-2 O-linked glycan; Galβ1-4GlcNAcβ1-6(Galβ1-3)GalNAcβ1-3Galα1-4Galβ1-4Glc; an (n)Lc-series GSL-glycan; GSL-21; GSL-33; GSL-35; GSL-38; and GSL-47.
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Inventors:
SHINOHARA YASURO (JP)
TANAKA SHINYA (JP)
FURUKAWA JUN-ICHI (JP)
TSUDA MASUMI (JP)
TANAKA SHINYA (JP)
FURUKAWA JUN-ICHI (JP)
TSUDA MASUMI (JP)
Application Number:
PCT/JP2015/072583
Publication Date:
February 11, 2016
Filing Date:
August 07, 2015
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
G01N33/574; G01N33/53; C12N15/09; C12Q1/34; C12Q1/68
Domestic Patent References:
| WO2006022114A1 | 2006-03-02 | |||
| WO2010064683A1 | 2010-06-10 | |||
| WO2008149526A1 | 2008-12-11 | |||
| WO2011138955A1 | 2011-11-10 |
Other References:
TSUCHIYA NAOTO: "Isolation and characterization of an N-linked oligosaccharide that is increased in glioblastoma tissue and cell lines", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 27, no. 5, 2005, pages 1231 - 9
KAZUHIRO IKENAKA: "Sialic Acid-ka N-Ketsugogata Tosa no Morateki Kaiseki ni yoru Gan no Bunrui", GRANT-IN-AIDS FOR SCIENTIFIC RESEARCH ON PRIORITY AREAS CANCER HEISEI 20 NENDO, 2009, pages 247
YAMAMOTO H: "a2,6-Sialylation of Cell -Surface N- Glycans Inhibits Glioma Formation in Vivo", CANCER RES, vol. 61, no. 18, 2001, pages 6822 - 6829
YASURO SHINOHARA: "Glioma Model Saibo o Mochiiru Fushika Ganka ni Tomonau Tosa Hatsugen Hendo no Kaiseki", THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, vol. 33, 2014, pages 60
KAZUHIRO IKENAKA: "Sialic Acid-ka N-Ketsugogata Tosa no Morateki Kaiseki ni yoru Gan no Bunrui", GRANT-IN-AIDS FOR SCIENTIFIC RESEARCH ON PRIORITY AREAS CANCER HEISEI 20 NENDO, 2009, pages 247
YAMAMOTO H: "a2,6-Sialylation of Cell -Surface N- Glycans Inhibits Glioma Formation in Vivo", CANCER RES, vol. 61, no. 18, 2001, pages 6822 - 6829
YASURO SHINOHARA: "Glioma Model Saibo o Mochiiru Fushika Ganka ni Tomonau Tosa Hatsugen Hendo no Kaiseki", THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, vol. 33, 2014, pages 60
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
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