Title:
GLP-1/GCG DUAL-ACCEPTOR AGONIST POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2021/083306
Kind Code:
A1
Abstract:
A GLP-1/GCG dual-acceptor agonist polypeptide. The polypeptide comprises an amino acid sequence as follows: 5
'X 1SQGT FTSDX 10 SKYLX 15 X 16X 17X 18AX 20 X 21FX 23X 24W L X 27X 28 X 29X 30
3
', wherein X 1 is H or Y, X 10 is Y or L, X 15 is D or E, X 16 is M or E, X 17 is Q, K, or R, X 18 is R or A, X 20 is H or K, X 21 is E or D, X 23 is V or I, X 24 is Q, A, N, or E, X 27 is L or M, X 28 is A, N, or D, X 29 is A or G, X 30 is T, and PSSGAPPPS may not exist. The GLP-1/GCG dual-acceptor agonist polypeptide has a good blood sugar-lowering and weight-losing effect, and a long in vivo half-life period, and is a more effective long acting weight-losing and blood sugar control drug.
Inventors:
JIANG PENG (CN)
HUANG LIMEI (CN)
LEI DAN (CN)
GE JIA (CN)
XIAO LIN (CN)
ZHOU LINJUN (CN)
WANG HUI (CN)
LING YI (CN)
ZHAN ZHIZHU (CN)
LI JINQING (CN)
YAN JIANGYU (CN)
LI JING (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)
HUANG LIMEI (CN)
LEI DAN (CN)
GE JIA (CN)
XIAO LIN (CN)
ZHOU LINJUN (CN)
WANG HUI (CN)
LING YI (CN)
ZHAN ZHIZHU (CN)
LI JINQING (CN)
YAN JIANGYU (CN)
LI JING (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)
Application Number:
PCT/CN2020/125110
Publication Date:
May 06, 2021
Filing Date:
October 30, 2020
Export Citation:
Assignee:
DONGGUAN HEC BIOPHARMACEUTICAL R&D CO LTD (CN)
International Classes:
A61K38/00; A61K38/26; A61K38/28; A61P3/04
Domestic Patent References:
| WO2011075393A2 | 2011-06-23 |
Foreign References:
| CN102105159A | 2011-06-22 | |||
| CN105324125A | 2016-02-10 | |||
| CN103179976A | 2013-06-26 | |||
| CN103179979A | 2013-06-26 | |||
| CN102892425A | 2013-01-23 | |||
| CN103402536A | 2013-11-20 | |||
| CN102123723A | 2011-07-13 | |||
| CN109836503A | 2019-06-04 |
Other References:
WANG, JING ET AL.: "Research Progress on Glucagon-Like Peptide-1/Glucagon Receptor Dual Agonism for the Treatment of Obesity", CHINESE JOURNAL OF HEALTH CARE AND MEDICINE, vol. 20, no. 1, 28 February 2018 (2018-02-28), pages 81 - 83, XP055807013
V. A. GAULT, V. K. BHAT, N. IRWIN, P. R. FLATT: "A Novel Glucagon-like Peptide-1 (GLP-1)/Glucagon Hybrid Peptide with Triple-acting Agonist Activity at Glucose-dependent Insulinotropic Polypeptide, GLP-1, and Glucagon Receptors and Therapeutic Potential in High Fat-fed Mice", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 288, no. 49, 6 December 2013 (2013-12-06), US, pages 35581 - 35591, XP055337195, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.512046
V. A. GAULT, V. K. BHAT, N. IRWIN, P. R. FLATT: "A Novel Glucagon-like Peptide-1 (GLP-1)/Glucagon Hybrid Peptide with Triple-acting Agonist Activity at Glucose-dependent Insulinotropic Polypeptide, GLP-1, and Glucagon Receptors and Therapeutic Potential in High Fat-fed Mice", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 288, no. 49, 6 December 2013 (2013-12-06), US, pages 35581 - 35591, XP055337195, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.512046
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