Title:
GLUCAGON DERIVATIVE HAVING IMPROVED STABILITY
Document Type and Number:
WIPO Patent Application WO/2016/108586
Kind Code:
A1
Abstract:
The present invention relates to a novel glucagon derivative peptide and a composition for preventing or treating hypoglycemia and obesity, including the peptide as an active ingredient. A glucagon derivative according to the present invention maintains activity against glucagon receptors and has enhanced physical properties due to modified pI, and thus is capable of improving patient compliance when being used as a medicine for hypoglycemia, and is suitable for concomitant administration with other anti-obesity medicines. Thus, the glucagon derivative according to the present invention can be usefully used in prevention or treatment of hypoglycemia and obesity.
Inventors:
KIM JUNG KUK (KR)
LEE JONG MIN (KR)
KIM SANG YUN (KR)
BAE SUNG MIN (KR)
JUNG SUNG YOUB (KR)
KWON SE CHANG (KR)
LEE JONG MIN (KR)
KIM SANG YUN (KR)
BAE SUNG MIN (KR)
JUNG SUNG YOUB (KR)
KWON SE CHANG (KR)
Application Number:
PCT/KR2015/014422
Publication Date:
July 07, 2016
Filing Date:
December 30, 2015
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
C07K14/605; A61K38/26; A61P3/04
Domestic Patent References:
| WO2011117415A1 | 2011-09-29 | |||
| WO2014170496A1 | 2014-10-23 |
Foreign References:
| US8507428B2 | 2013-08-13 | |||
| JP5476304B2 | 2014-04-23 |
Other References:
CHABENNE ET AL.: "A Glucagon Analog Chemically stabilized for Immediate Treatment of Life Threatening Hypoglycemia", MOLECULAR METABOLISM, vol. 3, January 2014 (2014-01-01), pages 293 - 300, XP055173894, DOI: doi:10.1016/j.molmet.2014.01.006
See also references of EP 3241841A4
See also references of EP 3241841A4
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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