Title:
GLUCAGON-LOADED MICRONEEDLE PATCH
Document Type and Number:
WIPO Patent Application WO/2024/077705
Kind Code:
A1
Abstract:
A glucagon-loaded microneedle patch, comprising an array composed of a plurality of microneedles and a substrate, each microneedle comprising a needle tip, a needle body, and a substrate surface. The microneedle patch is made of a polymer and a solubilizer and contains glucagon loaded thereon. When the ratio of the length of the microneedles to the distance between the tips of adjacent microneedles is 1.2-1.7, the longer the length of the microneedles, the faster the glucagon transdermal rate. The needle bodies and the substrate of the glucagon-loaded microneedle patch are all loaded with glucagon, achieving transdermal drug delivery, and the glucagon-loaded microneedle patch has the characteristics of first burst release and then sustained release, is quick to take effect, has a long action time, and can be used for rescue therapy of critical hypoglycemia.
Inventors:
ZHENG CHAO (CN)
YU XIANG (CN)
GU WEI (CN)
CHANG HAO (CN)
ZHANG YIKAI (CN)
XU JIANCHEN (CN)
YU XIANG (CN)
GU WEI (CN)
CHANG HAO (CN)
ZHANG YIKAI (CN)
XU JIANCHEN (CN)
Application Number:
PCT/CN2022/131856
Publication Date:
April 18, 2024
Filing Date:
November 15, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61M37/00; A61K9/00
Domestic Patent References:
| WO2022010698A1 | 2022-01-13 |
Foreign References:
| US20140371713A1 | 2014-12-18 | |||
| CN114376569A | 2022-04-22 | |||
| CN112641931A | 2021-04-13 | |||
| CN114306917A | 2022-04-12 | |||
| US20210128738A1 | 2021-05-06 |
Attorney, Agent or Firm:
SHANGHAI XINLONG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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