GLUCOCORTICOID BLOCKING AGENTS FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY

Title:

GLUCOCORTICOID BLOCKING AGENTS FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY

Document Type and Number:

WIPO Patent Application WO2002017930

Kind Code:

A3

Abstract:

Glucocorticoid blockers, including glucocorticoid receptor antagonists, are effetive to prevent glucocorticoid-induced decrease in permeability of the blood-brain barrier and to increase the permeability of the blood-brain barrier. Administration of glucocorticoid blockers, including glucocorticoid receptor antagonists, concomitant with administration of drugs for treating diseases of the central nervous system increases delivery of such drugs into the central nervous system.

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Inventors:

SCHATZBERG ALAN F (US)
BELANOFF JOSEPH K (US)
LINDLEY STEVEN (US)

Application Number:

PCT/US2001/027026

Publication Date:

May 16, 2002

Filing Date:

August 29, 2001

Export Citation:

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Assignee:

UNIV LELAND STANFORD JUNIOR (US)
SCHATZBERG ALAN F (US)
BELANOFF JOSEPH K (US)
LINDLEY STEVEN (US)

International Classes:

A61K31/00; A61K31/166; A61K31/40; A61K31/415; A61K31/4164; A61K31/4196; A61K31/439; A61K31/4439; A61K31/485; A61K31/495; A61K31/496; A61K31/5375; A61K31/5377; A61K31/567; A61K31/57; A61K45/06; A61P25/00; (IPC1-7): A61K31/573; A61K31/575; A61P25/00

Domestic Patent References:

WO1995017192A1

1995-06-29

Other References:

IWEN P C ET AL: "ENHANCEMENT OF KETOCONAZOLE PENETRATION ACROSS THE BLOOD-BRAIN BARRIER OF MICE BY DIMETHYL SULFOXIDE", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 30, no. 4, October 1986 (1986-10-01), pages 617 - 618, XP001055988, ISSN: 0066-4804
PERFECT J R ET AL: "COMPARISON OF ITRACONAZOLE AND FLUCONAZOLE IN TREATMENT OF CRYPTOCOCCAL MENINGITIS AND CANDIDA PYELONEPHRITIS IN RABBITS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 29, no. 4, April 1986 (1986-04-01), pages 579 - 583, XP001057087, ISSN: 0066-4804
GAILLARD ET AL: "CORICOSTEROID REGULATION OF BBB PERMEABILITY", SOCIETY FOR NEUROSCIENCE, vol. 23, 1997, pages 229, XP001057484

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