Title:
GLUCOREGULATORY COMPOUND, COMPOSITION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/098817
Kind Code:
A1
Abstract:
The invention provides an isolated glucoregulatory compound having both insulinotropic and blood glucose lowering activities. The compound is a glucoregulatory peptide derived from cysteine rich transmembrane module containing 1 (CYSTM1). Also provided is a composition comprising the compound and uses thereof for treating diseases associated with insulin deficiency or failure in glucose uptake independent of insulin secretion by pancreatic cells such as hyperglycemia, type 1 diabetes, or type 2 diabetes mellitus in a subject.
Inventors:
WONG CHI MING (CN)
LO TAK HO (CN)
LO TAK HO (CN)
Application Number:
PCT/CN2022/135913
Publication Date:
June 08, 2023
Filing Date:
December 01, 2022
Export Citation:
Assignee:
UNIV HONG KONG POLYTECHNIC (CN)
International Classes:
A61K38/17; C07K14/435; A61P3/08
Foreign References:
| EP2341066A1 | 2011-07-06 | |||
| US20160145687A1 | 2016-05-26 | |||
| CN105473743A | 2016-04-06 |
Other References:
T. M. VENANCIO, L. ARAVIND: "CYSTM, a novel cysteine-rich transmembrane module with a role in stress tolerance across eukaryotes", BIOINFORMATICS, OXFORD UNIVERSITY PRESS, vol. 26, no. 2, 15 January 2010 (2010-01-15), pages 149 - 152, XP055122821, ISSN: 13674803, DOI: 10.1093/bioinformatics/btp647
MASTROKOLIAS ANASTASIOS, ARIYUREK YAVUZ, GOEMAN JELLE J, VAN DUIJN ERIK, ROOS RAYMUND AC, VAN DER MAST ROOS C, VAN OMMEN GERTJAN B: "Huntington’s disease biomarker progression profile identified by transcriptome sequencing in peripheral blood", EUROPEAN JOURNAL OF HUMAN GENETICS, KARGER, BASEL, CH, vol. 23, no. 10, 1 October 2015 (2015-10-01), CH , pages 1349 - 1356, XP093069545, ISSN: 1018-4813, DOI: 10.1038/ejhg.2014.281
MASTROKOLIAS ANASTASIOS, ARIYUREK YAVUZ, GOEMAN JELLE J, VAN DUIJN ERIK, ROOS RAYMUND AC, VAN DER MAST ROOS C, VAN OMMEN GERTJAN B: "Huntington’s disease biomarker progression profile identified by transcriptome sequencing in peripheral blood", EUROPEAN JOURNAL OF HUMAN GENETICS, KARGER, BASEL, CH, vol. 23, no. 10, 1 October 2015 (2015-10-01), CH , pages 1349 - 1356, XP093069545, ISSN: 1018-4813, DOI: 10.1038/ejhg.2014.281
Attorney, Agent or Firm:
BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)
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