Title:
GLUT4 ENDOCYTOSIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2015/108134
Kind Code:
A1
Abstract:
The present invention provides: a therapeutic agent for diabetes, particularly a therapeutic agent for diabetes which can inhibit the activation of PKCα to thereby exhibit a GLUT4 endocytosis inhibitory activity, said therapeutic agent containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) as an active ingredient; and others.
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Inventors:
NISHIZAKI TOMOYUKI (JP)
Application Number:
PCT/JP2015/051022
Publication Date:
July 23, 2015
Filing Date:
January 16, 2015
Export Citation:
Assignee:
NISHIZAKI BIOINFORMATION RES INST (JP)
International Classes:
A61K31/685; A61P3/04; A61P3/06; A61P3/10; A61P43/00
Domestic Patent References:
| WO2009028220A1 | 2009-03-05 |
Foreign References:
| JP2006524707A | 2006-11-02 | |||
| JPH08507929A | 1996-08-27 | |||
| JP2004513919A | 2004-05-13 | |||
| JP2005527582A | 2005-09-15 | |||
| RU2309614C1 | 2007-11-10 | |||
| JP2005247728A | 2005-09-15 |
Other References:
TANA ET AL., JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 59, no. 7, 1997, pages 617 - 619, XP002993228
TSUCHIYA A ET AL., LIFE SCIENCES, vol. 93, no. 5-6, August 2013 (2013-08-01), pages 240 - 246, XP028681583
YAGUCHI T; NAGATA T; NISHIZAKI T.: "Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha-7 nicotinic ACh receptors", LIFE SCI, vol. 84, 2009, pages 263 - 266, XP055174884, DOI: doi:10.1016/j.lfs.2008.12.003
YAGUCHI T; NAGATA T; NISHIZAKI T.: "1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine improves cognitive decline by enhancing long-term depression", BEHAV BRAIN RES, vol. 204, 2009, pages 129 - 132, XP026422139
KIKKAWA ET AL., J. BIOL. CHEM., vol. 257, 1982, pages 13341
KANNO T ET AL., J LIPID RES, vol. 47, 2006, pages 1146 - 1156
TSUCHIYA A ET AL., LIFE SCIENCES, vol. 93, no. 5-6, August 2013 (2013-08-01), pages 240 - 246, XP028681583
YAGUCHI T; NAGATA T; NISHIZAKI T.: "Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha-7 nicotinic ACh receptors", LIFE SCI, vol. 84, 2009, pages 263 - 266, XP055174884, DOI: doi:10.1016/j.lfs.2008.12.003
YAGUCHI T; NAGATA T; NISHIZAKI T.: "1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine improves cognitive decline by enhancing long-term depression", BEHAV BRAIN RES, vol. 204, 2009, pages 129 - 132, XP026422139
KIKKAWA ET AL., J. BIOL. CHEM., vol. 257, 1982, pages 13341
KANNO T ET AL., J LIPID RES, vol. 47, 2006, pages 1146 - 1156
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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