Title:
GLUTAMIC ACID RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/1996/025926
Kind Code:
A1
Abstract:
A glutamic acid receptor agonist which comprises as the active ingredient sulfonamide derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof wherein A represents naphthyl, pyridyl, phenyl optionally having 1 to 5 substituents selected from the group consisting of halogeno, C1-4 alkyl, C1-4 alkoxy, nitro and acetamido, or C1-20 alkyl; B represents C1-3 alkylene, -OCH2- or -CH=CH-; X and Y are the same or different and each represents hydrogen or fluoro; R represents carboxy, C2-5 alkoxycarbonyl, hydroxymethyl or (a) (wherein R1 represents hydrogen or C1-3 alkyl; and R2 represents hydrogen, hydroxy, C1-3 alkyl, carboxymethyl or C3-6 alkoxycarbonyl); m represents an integer of 0 to 2 and n represents an integer of 0 to 3. The agonist is efficatious in the prevention and treatment of nerve degeneration in morbid conditions.
Inventors:
TAKEO JIRO (JP)
YAMASHITA SHINYA (JP)
WADA KEIJI (JP)
CHIBA YOSHIYUKI (JP)
YAMASHITA SHINYA (JP)
WADA KEIJI (JP)
CHIBA YOSHIYUKI (JP)
Application Number:
PCT/JP1996/000379
Publication Date:
August 29, 1996
Filing Date:
February 20, 1996
Export Citation:
Assignee:
NIPPON SUISAN KAISHA LTD (JP)
TAKEO JIRO (JP)
YAMASHITA SHINYA (JP)
WADA KEIJI (JP)
CHIBA YOSHIYUKI (JP)
TAKEO JIRO (JP)
YAMASHITA SHINYA (JP)
WADA KEIJI (JP)
CHIBA YOSHIYUKI (JP)
International Classes:
A61K31/00; A61K31/18; A61K31/192; A61K31/195; A61K31/216; A61K31/4035; A61K31/4406; C07C317/28; C07C323/49; C07C323/56; C07C323/62; (IPC1-7): A61K31/18; A61K31/195; A61K31/215; A61K31/44
Foreign References:
| JPH04364158A | 1992-12-16 | |||
| JPH02196764A | 1990-08-03 |
Other References:
See also references of EP 0811375A4
Download PDF: