Title:
GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS
Document Type and Number:
WIPO Patent Application WO/2021/054927
Kind Code:
A3
Abstract:
The present invention describes compositions containing cholesterol-linker-glutathione conjugates for targeting the brain by overcoming barrier entry to the CNS through the blood brain barrier (BBB), including micelle and liposome forms of such compositions. In addition, methods for treating subjects by administering such compositions are also disclosed.
Inventors:
GUAN XIANGMING (US)
NAJMI ASIDIM (US)
WANG SHENGGANG (US)
HUANG YUE (US)
SEEFELDT TERESA (US)
ALQAHTANI YAHYA (US)
NAJMI ASIDIM (US)
WANG SHENGGANG (US)
HUANG YUE (US)
SEEFELDT TERESA (US)
ALQAHTANI YAHYA (US)
Application Number:
PCT/US2019/000039
Publication Date:
March 03, 2022
Filing Date:
August 12, 2019
Export Citation:
Assignee:
SOUTH DAKOTA BOARD OF REGENTS (US)
International Classes:
A61K9/14; A61K9/127; A61K9/51; A61K47/28
Domestic Patent References:
| WO1986003299A1 | 1986-06-05 | |||
| WO2015153345A1 | 2015-10-08 | |||
| WO2009009025A1 | 2009-01-15 | |||
| WO2018035476A1 | 2018-02-22 |
Foreign References:
| US20080095836A1 | 2008-04-24 | |||
| AU2014259532B2 | 2016-09-08 |
Attorney, Agent or Firm:
BASHAM, Daryl, A. (US)
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