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Title:
GLYCINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/034078
Kind Code:
A1
Abstract:
Disclosed is a compound which is useful as the active ingredient of a medicinal composition, in particular, a medicinal composition for preventing and/or treating a VAP-1 associated disease. As the results of intensive studies on compounds having VAP-1 inhibitory activity, it was discovered that the aforesaid compound or a salt thereof shows an excellent VAP-1 inhibitory activity and, therefore, is useful in preventing and/or treating a VAP-1 associated disease, in particular, diabetic nephropathy or diabetic macular edema. The present invention has been thus completed. Also disclosed is a medicinal composition, in particular a medicinal composition for preventing and/or treating a VAP-1 associated disease, which comprises the aforesaid compound or a salt thereof and an excipient.

Inventors:
YOSHIHARA KOUSEI (JP)
SUZUKI DAISUKE (JP)
YAMAKI SUSUMU (JP)
KOGA YUJI (JP)
SEKI NORIO (JP)
FUJIYASU JIRO (JP)
NEYA MASAHIRO (JP)
Application Number:
JP2010/065918
Publication Date:
March 24, 2011
Filing Date:
September 15, 2010
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
YOSHIHARA KOUSEI (JP)
SUZUKI DAISUKE (JP)
YAMAKI SUSUMU (JP)
KOGA YUJI (JP)
SEKI NORIO (JP)
FUJIYASU JIRO (JP)
NEYA MASAHIRO (JP)
International Classes:
C07C237/04; A61K31/165; A61K31/166; A61K31/167; A61K31/17; A61K31/18; A61K31/216; A61K31/27; A61K31/277; A61K31/351; A61K31/357; A61K31/40; A61K31/4035; A61K31/4402; A61K31/4406; A61K31/4418; A61K31/4439; A61K31/451; A61K31/454; A61K31/4545; A61K31/472; A61K31/495; A61K31/496; A61K31/505; A61K31/506; A61K31/5375; A61K31/5377; A61K31/54; A61K31/541; A61K31/55; A61K31/551; A61K31/553; C07C237/06; C07C237/08; C07C237/10; C07C237/12; C07C237/42; C07C255/60; C07C271/28; C07C275/40; C07C311/08; C07C311/21; C07C311/46; C07C317/40; C07D207/09; C07D207/12; C07D207/14; C07D207/26; C07D209/44; C07D211/46; C07D211/58; C07D211/60; C07D211/62; C07D213/40; C07D213/61; C07D213/65; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D217/26; C07D223/12; C07D239/34; C07D239/42; C07D243/08; C07D265/30; C07D267/10; C07D295/12; C07D295/14; C07D295/18; C07D295/20; C07D295/22; C07D309/04; C07D309/14; C07D319/18; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/12; C07D407/14; C07D413/04; C07D413/12; C07D417/04; C07D471/04; C07D487/04; C07D513/04; A61P1/00; A61P1/02; A61P1/16; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P29/00; A61P37/02; A61P37/08; A61P43/00
Domestic Patent References:
WO2007018319A12007-02-15
WO1993023023A11993-11-25
WO2002002090A22002-01-10
WO2002002541A22002-01-10
WO2002038152A12002-05-16
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WO2005082343A22005-09-09
WO2009055002A12009-04-30
WO2004067521A12004-08-12
Foreign References:
JP2007500707A2007-01-18
JP2002080439A2002-03-19
JP2000178243A2000-06-27
JPS61239891A1986-10-25
US4888283A1989-12-19
US20020173521A12002-11-21
Other References:
PURANDARE A V, ET AL.: "Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 15, 28 June 2008 (2008-06-28), pages 4438 - 4441, XP023521570
See also references of EP 2479165A4
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P. G. M. WUTS AND T. W. GREENE,: "Greene's Protective Groups in Organic Synthesis(4" Ed.,)", 2006, P. G. M. WUTS AND T. W. GREENE
SYNTHESIS, vol. 4, 2006, pages 629 - 632
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations, 2nd edition,", vol. 1, 1991, ACADEMIC PRESS INC.
MARUZEN: "Courses in Experimental Chemistry(5th edition)", vol. 14, 2005, MARUZEN
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
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