Title:
GLYCINE TRANSPORTER INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/199960
Kind Code:
A1
Abstract:
The present invention provides a novel compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, a specific phobia, acute stress disorder and the like), depression, drug dependence, convulsion, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder and sleep disorder, on the basis of an inhibitory activity on glycine uptake.
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Inventors:
YAMADA YOUSUKE (JP)
OHTA HIROSHI (JP)
TAMITA TOMOKO (JP)
ABE KUMI (JP)
YAMAMOTO SHUJI (JP)
SHIROKAWA SHIN-ICHI (JP)
ABE MASAHITO (JP)
MATSUDA YOHEI (JP)
ARAKI YUKO (JP)
OHTA HIROSHI (JP)
TAMITA TOMOKO (JP)
ABE KUMI (JP)
YAMAMOTO SHUJI (JP)
SHIROKAWA SHIN-ICHI (JP)
ABE MASAHITO (JP)
MATSUDA YOHEI (JP)
ARAKI YUKO (JP)
Application Number:
PCT/JP2014/065269
Publication Date:
December 18, 2014
Filing Date:
June 09, 2014
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07C233/73; A61K31/166; A61K31/277; A61K31/415; A61K31/44; A61K31/4439; A61K31/444; A61K31/4725; A61K31/497; A61K31/505; A61K31/506; A61P1/00; A61P21/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P43/00; C07C233/76; C07C235/48; C07C255/60; C07D213/40; C07D213/81; C07D231/12; C07D239/26; C07D401/04; C07D401/12; C07D403/12; C07D471/04; C07D498/04
Domestic Patent References:
| WO2011161008A1 | 2011-12-29 | |||
| WO2006134341A1 | 2006-12-21 |
Foreign References:
| JP2008543817A | 2008-12-04 | |||
| JP2008542348A | 2008-11-27 | |||
| JP2005519859A | 2005-07-07 |
Other References:
EPSZTAJN, JAN ET AL.: "Applications of organolithium and related reagents in synthesis. Part 5. Directed metalation of secondary picolin- and isonicotinamides. A useful method for the synthesis of 2,3- and 3,4-disubstituted pyridines, including furo [3,4-b]pyridin-3(lH)-one and furo[3,4-c] pyridin-1(3H)-one", JOURNAL OF CHEMICAL RESEARCH, SYNOPSES, 1986, pages 20 - 21, XP002419150
MOLECULAR PSYCHIATRY, vol. 9, 2004, pages 984 - 997
CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 1017 - 1044
NEUROPSYCHOPHARMACOLOGY, vol. 30, 2005, pages 1963 - 1985
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 2, 2004, pages 201 - 214
THEODORA W. GREENE; PETER G.M. WUTS: "Greene's Protective Groups in Organic Synthesis", WILEY INTERSCIENCE
THEODORA W. GREENE; PETER G.M. WUTS: "Greene's Protective Groups in Organic Synthesis"
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis"
THEODORA W. GREENE; PETER G.M. WUTS: "Protective Groups in Organic Synthesis"
NEURON, vol. 8, 1992, pages 927 - 935
MOLECULAR PSYCHIATRY, vol. 9, 2004, pages 984 - 997
CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 1017 - 1044
NEUROPSYCHOPHARMACOLOGY, vol. 30, 2005, pages 1963 - 1985
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 2, 2004, pages 201 - 214
THEODORA W. GREENE; PETER G.M. WUTS: "Greene's Protective Groups in Organic Synthesis", WILEY INTERSCIENCE
THEODORA W. GREENE; PETER G.M. WUTS: "Greene's Protective Groups in Organic Synthesis"
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis"
THEODORA W. GREENE; PETER G.M. WUTS: "Protective Groups in Organic Synthesis"
NEURON, vol. 8, 1992, pages 927 - 935
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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