GLYCOPEPTIDE DIMERS AND USES THEREOF

Title:

GLYCOPEPTIDE DIMERS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO2006017180

Kind Code:

A3

Abstract:

This invention provides compounds represented by the formula: (A-X---)_nwherein each A- is independently a carbohydrate represented by the general structure: wherein each of B, C, D, E, F, G, H, I, and J independently represents a sugar moiety, a sugar moiety having a protecting group attached thereto, a hydrogen, or an oxygen protecting group, provided that no more than two of B, C, D, and E is simultaneously a sugar moiety or a sugar moiety having a protecting group attached thereto and that no more than one of F, G, H, and I is simultaneously a sugar moiety or a sugar moiety having a protecting group attached thereto and wherein represents a covalent bond between the carbohydrate and the peptide; wherein each R¹ independently represents a hydrogen or an oxygen protecting group; wherein each R^2Aand each R^2Bis independently a hydrogen or a nitrogen protecting group; wherein X is a peptide; wherein --- represents a disulfide bond; and wherein n represents an integer = 2.

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Inventors:

DANISHEFSKY SAMUEL (US)
DUDKIN VADIM (US)
GENG XUDONG (US)
MANDAL MIHIRIBARAN (US)
OLSON WILLIAM (US)
ORLOVA MARIANNA (US)

Application Number:

PCT/US2005/024273

Publication Date:

July 20, 2006

Filing Date:

July 08, 2005

Export Citation:

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Assignee:

PROGENICS PHARM INC (US)
SLOAN KETTERING INST CANCER (US)
DANISHEFSKY SAMUEL (US)
DUDKIN VADIM (US)
GENG XUDONG (US)
MANDAL MIHIRIBARAN (US)
OLSON WILLIAM (US)
ORLOVA MARIANNA (US)

International Classes:

A61K38/16

Other References:

DUDKIN V.Y. ET AL.: "Toward Fully Synthetic Carbohydrate-Based HIV Antigen Design: On the Critical Role of Bivalency", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 11 August 2004 (2004-08-11), pages 9560 - 9562, XP002995531, DOI: doi:10.1021/ja047720g
SINGH S. ET AL.: "Chemoenzymatic Synthesis of High-Mannose Type HIV-1 Gp120 Glycopeptides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 327 - 330, XP002306980, DOI: doi:10.1016/S0960-894X(02)01025-9

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