Title:
GLYCOPEPTIDES AND TEMPERATURE-RESPONSIVE MICELLES
Document Type and Number:
WIPO Patent Application WO/2005/051982
Kind Code:
A1
Abstract:
It is intended to provide temperature-responsive amphiphilic glycopeptides and temperature-responsive micelles. Namely, a glycopeptide which would not occur in nature and is represented by the following general formula (1) and a temperature-responsive micelle comprising the glycopeptide. [Chemical formula 1] (1) wherein X represents an arbitrary amino acid residue; L1 and L2 represent each a linker; SUG represents a sugar chain; m is 0 or 1; and n is an integer of from 1 to 10, provided that L1 and L2 may be either the same or different from each other and a plural number of SUGs may be either the same or different from each other.
Inventors:
MIURA KEIKO (JP)
SHIBATA CHIERI (JP)
KOBAYASHI KAZUKIYO (JP)
SHIBATA CHIERI (JP)
KOBAYASHI KAZUKIYO (JP)
Application Number:
PCT/JP2004/007246
Publication Date:
June 09, 2005
Filing Date:
May 27, 2004
Export Citation:
Assignee:
TOAGOSEI CO LTD (JP)
MIURA KEIKO (JP)
SHIBATA CHIERI (JP)
KOBAYASHI KAZUKIYO (JP)
MIURA KEIKO (JP)
SHIBATA CHIERI (JP)
KOBAYASHI KAZUKIYO (JP)
International Classes:
A61K9/107; C07K9/00; C07K14/00; (IPC1-7): C07K7/06; A61K47/42
Other References:
SHIBATA C. ET AL.: "Thermo-Responsive Glycopeptides ; Synthesis and Properties (Abstarct IIPe143)", POLYMER PREPRINTS, SOCIETY OF POLYMER SCIENCE, vol. 52, no. 5, 8 May 2003 (2003-05-08), JAPAN, pages 1066, XP002996293
MIURA Y. ET AL: "Ondo Otosei To-peptide no gosei to Kino Kaiseki", POLYMER PREPRINTS, vol. 52, no. 13, 10 September 2003 (2003-09-10), JAPAN, pages 3771 - 3772, XP002996294
URRY D.W. ET AL: "Physical Chemistry of Biological Free Energy Transduction as Demonstrated by Elastic Protein-Based Polymers.", PHYSICAL CHEMISTRY B, vol. 101, no. 51, 1997, pages 11007 - 11028, XP001021863
MCMILLAN R.A. ET AL: "High-Resolution Topographic, Elastin-Mimetic Hydrogels.", MACROMOLECULES, vol. 32, no. 26, 1999, pages 9067 - 9070, XP002996296
VAN HEST J. ET AL: "Bionspired triblock copolymers prepared by atom transfer radical copolymerization.", ACS SYMPOSIUM SERIES (CHAPTER 28), vol. 854, 2003, pages 394 - 410, XP002996297
ST.HILAIRE P. ET AL: "Oligosaccharide Mimentics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded. Glycopeptide Libraries.", RHE AMERICAN CHEMICAL, vol. 120, no. 51, 1998, pages 13312 - 13320, XP002210138
MIURA Y. ET AL: "Ondo Otosei To-peptide no gosei to Kino Kaiseki", POLYMER PREPRINTS, vol. 52, no. 13, 10 September 2003 (2003-09-10), JAPAN, pages 3771 - 3772, XP002996294
URRY D.W. ET AL: "Physical Chemistry of Biological Free Energy Transduction as Demonstrated by Elastic Protein-Based Polymers.", PHYSICAL CHEMISTRY B, vol. 101, no. 51, 1997, pages 11007 - 11028, XP001021863
MCMILLAN R.A. ET AL: "High-Resolution Topographic, Elastin-Mimetic Hydrogels.", MACROMOLECULES, vol. 32, no. 26, 1999, pages 9067 - 9070, XP002996296
VAN HEST J. ET AL: "Bionspired triblock copolymers prepared by atom transfer radical copolymerization.", ACS SYMPOSIUM SERIES (CHAPTER 28), vol. 854, 2003, pages 394 - 410, XP002996297
ST.HILAIRE P. ET AL: "Oligosaccharide Mimentics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded. Glycopeptide Libraries.", RHE AMERICAN CHEMICAL, vol. 120, no. 51, 1998, pages 13312 - 13320, XP002210138
Download PDF: