GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF

Title:

GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2007/041969

Kind Code:

A1

Abstract:

The present application belongs to pharmaceutical field of inflammation, immunity and infection. The present application has disclosed glycyrrhetinic acid-30-acidamide derivatives and their preparation methods, as well as pharmaceutical compositions containing the same. The said derivatives and their compositions have the activities of anti-inflammatory, analgesia, ananaphylaxis, relieving cough or codeine, liver-protecting and antivirus. The definitions of substituents are the same as description.

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Inventors:

WANG JIANWU (CN)
XU WEIREN (CN)
YONG JIANPING (CN)
TANG LIDA (CN)
ZHANG SHIJUN (CN)
LIU LIJUN (CN)
WANG YULI (CN)
REN XIAOWEN (CN)

Application Number:

PCT/CN2006/002711

Publication Date:

April 19, 2007

Filing Date:

October 16, 2006

Export Citation:

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Assignee:

TIANJIN INST PHARM RESEARCH (CN)
WANG JIANWU (CN)
XU WEIREN (CN)
YONG JIANPING (CN)
TANG LIDA (CN)
ZHANG SHIJUN (CN)
LIU LIJUN (CN)
WANG YULI (CN)
REN XIAOWEN (CN)

International Classes:

C07D407/04; A61K8/49; A61P1/16; A61P11/14; A61P25/04; A61P31/12; A61P37/08; C07D261/14; C07D409/04

Foreign References:

CN1563073A	2005-01-12
EP1449847A1	2004-08-25
GB2140809A	1984-12-05
GB1516271A	1978-06-28
GB1447162A	1976-08-25

Other References:

UM S.-J. ET AL.: "Synthesis of new glycyrrhetinic acid (GA) derivatives and their effects on tyrosinase activity", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 24, 2003, pages 5345 - 5352, XP002278450
LIANG QING: "Pseudo-aldosteronosis caused by glycyrrhizic acid", CHINESE TRADITIONAL AND HERBAL DRUGS COMMUNICATION, vol. 6, 1979, pages 45 - 46
WU P.; ZHANG Y.; LIUY.: "Effects of glycyrrhizin on production of vascular aldosterone and corticosterone", HORM - RES., vol. 51, no. 4, 1999, pages 189 - 192

Attorney, Agent or Firm:

PEKSUNG INTELLECTUAL PROPERTY LTD. (35 Xueyuan Road Haidian District, Beijing 3, CN)

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